Gene Review:
CDC42 - cell division cycle 42
Homo sapiens
Synonyms:
CDC42Hs, Cell division control protein 42 homolog, G25K, G25K GTP-binding protein
- Flt-1-mediated down-regulation of endothelial cell proliferation through pertussis toxin-sensitive G proteins, beta gamma subunits, small GTPase CDC42, and partly by Rac-1. Zeng, H., Zhao, D., Mukhopadhyay, D. J. Biol. Chem. (2002)
- CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1. Lu, X., Wu, X., Plemenitas, A., Yu, H., Sawai, E.T., Abo, A., Peterlin, B.M. Curr. Biol. (1996)
- Adenovirus endocytosis requires actin cytoskeleton reorganization mediated by Rho family GTPases. Li, E., Stupack, D., Bokoch, G.M., Nemerow, G.R. J. Virol. (1998)
- Signal therapy of breast cancers by the HDAC inhibitor FK228 that blocks the activation of PAK1 and abrogates the tamoxifen-resistance. Hirokawa, Y., Arnold, M., Nakajima, H., Zalcberg, J., Maruta, H. Cancer Biol. Ther. (2005)
- Rho family GTPase Cdc42 is essential for the actin-based motility of Shigella in mammalian cells. Suzuki, T., Mimuro, H., Miki, H., Takenawa, T., Sasaki, T., Nakanishi, H., Takai, Y., Sasakawa, C. J. Exp. Med. (2000)
- Sequential implication of the mental retardation proteins ARHGEF6 and PAK3 in spine morphogenesis. Nod??-Langlois, R., Muller, D., Boda, B. J. Cell. Sci. (2006)
- Individual differences in the in vitro response to cyclosporin A (CsA): possible heterogeneity in the involvement of the CD28-B7/BB1 pathway. Masy, E., Labalette-Houache, M., Dessaint, J.P. Thérapie. (1994)
- Biology of the p21-activated kinases. Bokoch, G.M. Annu. Rev. Biochem. (2003)
- Phosphoinositides Specify Polarity during Epithelial Organ Development. Comer, F.I., Parent, C.A. Cell (2007)
- PTEN-Mediated Apical Segregation of Phosphoinositides Controls Epithelial Morphogenesis through Cdc42. Martin-Belmonte, F., Gassama, A., Datta, A., Yu, W., Rescher, U., Gerke, V., Mostov, K. Cell (2007)
- A Rich1/Amot Complex Regulates the Cdc42 GTPase and Apical-Polarity Proteins in Epithelial Cells. Wells, C.D., Fawcett, J.P., Traweger, A., Yamanaka, Y., Goudreault, M., Elder, K., Kulkarni, S., Gish, G., Virag, C., Lim, C., Colwill, K., Starostine, A., Metalnikov, P., Pawson, T. Cell (2006)
- Closing the GAP between Polarity and Vesicle Transport. Macara, I.G., Spang, A. Cell (2006)
- Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. Eisenmann, K.M., McCarthy, J.B., Simpson, M.A., Keely, P.J., Guan, J.L., Tachibana, K., Lim, L., Manser, E., Furcht, L.T., Iida, J. Nat. Cell Biol. (1999)
- Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization. Leung, T., Chen, X.Q., Tan, I., Manser, E., Lim, L. Mol. Cell. Biol. (1998)
- Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases. Benard, V., Bohl, B.P., Bokoch, G.M. J. Biol. Chem. (1999)
- Cdc42 and RhoB activation are required for mannose receptor-mediated phagocytosis by human alveolar macrophages. Zhang, J., Zhu, J., Bu, X., Cushion, M., Kinane, T.B., Avraham, H., Koziel, H. Mol. Biol. Cell (2005)
- Involvement of Cdc42 signaling in apoA-I-induced cholesterol efflux. Nofer, J.R., Feuerborn, R., Levkau, B., Sokoll, A., Seedorf, U., Assmann, G. J. Biol. Chem. (2003)
- Glucose- and GTP-dependent stimulation of the carboxyl methylation of CDC42 in rodent and human pancreatic islets and pure beta cells. Evidence for an essential role of GTP-binding proteins in nutrient-induced insulin secretion. Kowluru, A., Seavey, S.E., Li, G., Sorenson, R.L., Weinhaus, A.J., Nesher, R., Rabaglia, M.E., Vadakekalam, J., Metz, S.A. J. Clin. Invest. (1996)
- Fibronectin matrix regulates activation of RHO and CDC42 GTPases and cell cycle progression. Bourdoulous, S., Orend, G., MacKenna, D.A., Pasqualini, R., Ruoslahti, E. J. Cell Biol. (1998)
- The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function. Li, X., Bu, X., Lu, B., Avraham, H., Flavell, R.A., Lim, B. Mol. Cell. Biol. (2002)
- Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domain. Barfod, E.T., Zheng, Y., Kuang, W.J., Hart, M.J., Evans, T., Cerione, R.A., Ashkenazi, A. J. Biol. Chem. (1993)
- Spreading of differentiating human monocytes is associated with a major increase in membrane-bound CDC42. Aepfelbacher, M., Vauti, F., Weber, P.C., Glomset, J.A. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils. Szczur, K., Xu, H., Atkinson, S., Zheng, Y., Filippi, M.D. Blood (2006)
- Tyrosine phosphorylation of the Wiskott-Aldrich syndrome protein by Lyn and Btk is regulated by CDC42. Guinamard, R., Aspenström, P., Fougereau, M., Chavrier, P., Guillemot, J.C. FEBS Lett. (1998)
- Phylogenetic and structural analysis of the Drosophila melanogaster p21-activated kinase DmPAK3. Mentzel, B., Raabe, T. Gene (2005)
- Effector proteins exert an important influence on the signaling-active state of the small GTPase Cdc42. Phillips, M.J., Calero, G., Chan, B., Ramachandran, S., Cerione, R.A. J. Biol. Chem. (2008)
- A phosphatidylinositol 3-kinase-independent insulin signaling pathway to N-WASP/Arp2/3/F-actin required for GLUT4 glucose transporter recycling. Jiang, Z.Y., Chawla, A., Bose, A., Way, M., Czech, M.P. J. Biol. Chem. (2002)
- Cdc42 induces activation loop phosphorylation and membrane targeting of mixed lineage kinase 3. Du, Y., Böck, B.C., Schachter, K.A., Chao, M., Gallo, K.A. J. Biol. Chem. (2005)
- Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules. Tian, L., Nelson, D.L., Stewart, D.M. J. Biol. Chem. (2000)
- Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2. Low, B.C., Seow, K.T., Guy, G.R. J. Biol. Chem. (2000)
- Activation of p21-CDC42/Rac-activated kinases by CD28 signaling: p21-activated kinase (PAK) and MEK kinase 1 (MEKK1) may mediate the interplay between CD3 and CD28 signals. Kaga, S., Ragg, S., Rogers, K.A., Ochi, A. J. Immunol. (1998)
- Substrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2. Joseph, R.E., Norris, F.A. J. Biol. Chem. (2005)
- Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages. Linder, S., Nelson, D., Weiss, M., Aepfelbacher, M. Proc. Natl. Acad. Sci. U.S.A. (1999)
- The role of SPECs, small Cdc42-binding proteins, in F-actin accumulation at the immunological synapse. Ching, K.H., Kisailus, A.E., Burbelo, P.D. J. Biol. Chem. (2005)
- Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase. DerMardirossian, C., Schnelzer, A., Bokoch, G.M. Mol. Cell (2004)
- Cdc42 downregulates MMP-1 expression by inhibiting the ERK1/2 pathway. Deroanne, C.F., Hamelryckx, D., Ho, T.T., Lambert, C.A., Catroux, P., Lapière, C.M., Nusgens, B.V. J. Cell. Sci. (2005)
- Emodin inhibits tumor cell migration through suppression of the phosphatidylinositol 3-kinase-Cdc42/Rac1 pathway. Huang, Q., Shen, H.M., Ong, C.N. Cell. Mol. Life Sci. (2005)
- An electrostatic steering mechanism of Cdc42 recognition by Wiskott-Aldrich syndrome proteins. Hemsath, L., Dvorsky, R., Fiegen, D., Carlier, M.F., Ahmadian, M.R. Mol. Cell (2005)
- Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling. Asanuma, K., Yanagida-Asanuma, E., Faul, C., Tomino, Y., Kim, K., Mundel, P. Nat. Cell Biol. (2006)
- The Cdc42 and Rac1 GTPases are required for capillary lumen formation in three-dimensional extracellular matrices. Bayless, K.J., Davis, G.E. J. Cell. Sci. (2002)
- Activation of Rac2 and Cdc42 on Fc and complement receptor ligation in human neutrophils. Forsberg, M., Druid, P., Zheng, L., Stendahl, O., Särndahl, E. J. Leukoc. Biol. (2003)