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Gene Review

FNBP4  -  formin binding protein 4

Homo sapiens

Synonyms: FBP30, Formin-binding protein 30, Formin-binding protein 4, KIAA1014
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High impact information on FNBP4

  • Here we demonstrate that the proposed adapter protein for Src kinases, Sam68, is a ligand whose proline-rich motifs interact with the SH3 domains of p59(fyn) and phospholipase Cgamma-1 as well as with the WW domains of FBP30 and FBP21 [1].
  • The asymmetrical dimethylation of arginine residues within these RG repeats dramatically reduces the binding of the SH3 domains of p59(fyn) and phospholipase Cgamma-1, but has no effect on their binding to the WW domain of FBP30 [1].


  1. Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains. Bedford, M.T., Frankel, A., Yaffe, M.B., Clarke, S., Leder, P., Richard, S. J. Biol. Chem. (2000) [Pubmed]
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