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Gene Review:

Zfp68 - zinc finger protein 68

Mus musculus

Synonyms: KRAB3, KRAZ2, Zfp70, mszf22, mszf49

Matsuda, E. et al., Agata, Y. et al.

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High impact information on Zfp68

Here we show that two KRAB-ZFPs that we previously identified, KRAZ1 and KRAZ2, are targeted to foci of centromeric heterochromatin containing HP1alpha through the interaction with KAP-1 [1].

Biological context of Zfp68

We have isolated two novel Krüppel-like zinc finger proteins containing the evolutionarily conserved Krüppel-associated box (KRAB), KRAZ1 and KRAZ2, and demonstrated that they repress transcription when heterologously targeted to DNA [2].

References

Targeting of Krüppel-associated box-containing zinc finger proteins to centromeric heterochromatin. Implication for the gene silencing mechanisms. Matsuda, E., Agata, Y., Sugai, M., Katakai, T., Gonda, H., Shimizu, A. J. Biol. Chem. (2001) [Pubmed]
Two novel Krüppel-associated box-containing zinc-finger proteins, KRAZ1 and KRAZ2, repress transcription through functional interaction with the corepressor KAP-1 (TIF1beta/KRIP-1). Agata, Y., Matsuda, E., Shimizu, A. J. Biol. Chem. (1999) [Pubmed]

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