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Gene Review:

Edpm1 - Estrogen-dependent pituitary mass QTL 1

Rattus norvegicus

Wendell, D.L. et al., Cracchiolo, D. et al., Wendell, D.L. et al.

Wendell, Daun, Stratton, Gorski,

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High impact information on Edpm1

To examine the effect of the Edpm QTL on biochemical components of tumor growth, we tested their effects in 138 progeny of a backcross to the F344 strain which were given a 10-week chronic estrogen treatment [1].
Estrogen-dependent pituitary growth is due to variation in a group of quantitative trait loci (QTL), called Edpm for estrogen-dependent pituitary mass, that we previously identified in an F(2) intercross of F344 and the tumor-resistant Brown Norway strain [1].
In contrast, the QTL Edpm2-1 and Edpm9-2, which have been shown to each have a significant effect on estrogen-dependent pituitary mass of a magnitude similar to Edpm5, do not have any effect on VEGF level [2].

Biological context of Edpm1

We have identified five quantitative trait loci (QTL) for estrogen-dependent pituitary mass (Edpm) in an F2 intercross of F344 and BN [3].

References

Different functions of QTL for estrogen-dependent tumor growth of the rat pituitary. Wendell, D.L., Daun, S.B., Stratton, M.B., Gorski, J. Mamm. Genome (2000) [Pubmed]
Estrogen-dependent growth of a rat pituitary tumor involves, but does not require, a high level of vascular endothelial growth factor. Cracchiolo, D., Swick, J.W., McKiernan, L., Sloan, E., Raina, S., Sloan, C., Wendell, D.L. Exp. Biol. Med. (Maywood) (2002) [Pubmed]
Quantitative trait loci for estrogen-dependent pituitary tumor growth in the rat. Wendell, D.L., Gorski, J. Mamm. Genome (1997) [Pubmed]

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