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Gene Review

cut15  -  karyopherin Cut15

Schizosaccharomyces pombe 972h-

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High impact information on cut15

  • The gene product of cut15+ is, surprisingly, very similar to importin alpha, which binds proteins containing a nuclear localization signal (NLS) and forms the heterodimer with importin beta that mediates translocation through the nuclear pore complex [1].
  • In contrast to cut15, imp1 is not essential for viability, but imp1delta mutant cells exhibit a telophase delay and mild temperature-sensitive lethality [2].


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