The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Telophase

  • Here we show that Sir2 executes these functions as a component of a nucleolar complex designated RENT (regulator of nucleolar silencing and telophase exit) [1].
  • In addition, loss of ASE1 function destabilized telophase spindles, and expression of a nondegradable Ase1 mutant delayed spindle disassembly [2].
  • However, as mitosis progressed, calpain II relocated to (i) an association with mitotic chromosomes, (ii) a perinuclear location in anaphase, and (iii) a mid-body location in telophase [3].
  • Silencing within the yeast rDNA repeats inhibits hyperrecombination, represses transcription from foreign promoters, and extends replicative life span. rDNA silencing is mediated by a Sir2-containing complex called RENT (regulator of nucleolar silencing and telophase exit) [4].
  • We suggest that PAV-KLP is required both to establish the structure of the telophase spindle to provide a framework for the assembly of the contractile ring, and to mobilize mitotic regulator proteins [5].

Biological context of Telophase

  • NuMA must also play a key role in telophase, as NuMA antibodies or truncations of NuMA cause aberrant nuclear reassembly despite apparently normal chromosome segregation [6].
  • During interphase, CRMP-1 protein was present uniformly throughout the cytoplasm and sometimes in the nucleus; during mitosis, CRMP-1 was associated with mitotic spindles, centrosomes, and the midbody (in late telophase) [7].
  • DBF2 encodes a protein kinase which is cell cycle regulated, peaking in metaphase-anaphase B/telophase, but its function remains unknown [8].
  • MCAK appears concentrated on centromeres at prophase and persists until telophase, after which time the localization disperses [9].
  • As mitosis progresses, NuMA reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident [10].

Anatomical context of Telophase

  • After nuclear envelope breakdown p57 becomes uniformly distributed throughout the mitotic cytoplasm until in late telophase when it returns to its perinuclear location and is once again excluded from the nucleus [11].
  • Computer analysis of the x-ray spectra allowed elemental microanalysis of the nucleus, cytoplasm, and late anaphase-early telophase chromatin regions in the cryptal and villus enterocytes [12].
  • The number and size of mitotic coiled bodies remain approximately unchanged from metaphase to early telophase while snRNP-containing clusters of mitotic interchromatin granules increase in size and number as cells progress from anaphase to telophase [13].
  • As the phragmoplast microtubules were redistributed from the center to the periphery during telophase, MMK3 still localized to the whole plane of division; thus, phragmoplast microtubules are not required to keep MMK3 at this location [14].
  • Here we show that the phosphatase activity of SSH1 decreases in the early stages of mitosis and is elevated in telophase and cytokinesis in HeLa cells, a time course correlating with that of cofilin dephosphorylation [15].

Associations of Telophase with chemical compounds

  • Depolymerization of microtubules by short treatments with the drug amiprophosmethyl during anaphase and telophase abolished MMK3 activity, indicating that intact microtubules are required for MMK3 activation [14].
  • Fostriecin also hampers progression through the later stages of mitosis as determined by the absence of normal half-spindles, anaphase figures, and telophase figures [16].
  • Only in the absence of nocodazole, as the cells entered telophase, was an additional glycosphingolipid synthesized which was identified as GA2 (GalNAc(beta 1,4)Gal(beta 1,4)Glc(beta 1,1)Cer) [17].
  • Binucleate cells were formed by a short caffeine treatment which aborted the formation of the phragmoplast during telophase [18].
  • In stable transformants expressing GFP-fused full-length ASK under the tetracycline inducible promoter, GFP-ASK protein accumulates in nuclei at the telophase, but its binding to chromatin does not reach a maximum until late G1, whereas huCdc7 is imported into nuclei and binds to chromatin at early G1 [19].

Gene context of Telophase

  • At telophase I, mei-1 product colocalized with the chromatin at the spindle poles [20].
  • The defect of TEM1 was lethal, and the tem1-defective cells were arrested at telophase with high H1-kinase activity under restrictive conditions, indicating that TEM1 is required to exit from M phase [21].
  • At the end of telophase, a portion of Cdc15p is located at the mother-bud neck, suggesting a possible role for Cdc15p in cytokinesis [22].
  • PCL2 is already known to be expressed in late G1 and we find that, in addition, it is also regulated by Swi5 in telophase [23].
  • Around telophase, Hof1p is phosphorylated and the double rings merge into a single ring that contracts slightly and may colocalize with the actomyosin structure [24].

Analytical, diagnostic and therapeutic context of Telophase


  1. Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity. Straight, A.F., Shou, W., Dowd, G.J., Turck, C.W., Deshaies, R.J., Johnson, A.D., Moazed, D. Cell (1999) [Pubmed]
  2. APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle. Juang, Y.L., Huang, J., Peters, J.M., McLaughlin, M.E., Tai, C.Y., Pellman, D. Science (1997) [Pubmed]
  3. Calpain II involvement in mitosis. Schollmeyer, J.E. Science (1988) [Pubmed]
  4. Association of the RENT complex with nontranscribed and coding regions of rDNA and a regional requirement for the replication fork block protein Fob1 in rDNA silencing. Huang, J., Moazed, D. Genes Dev. (2003) [Pubmed]
  5. pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis. Adams, R.R., Tavares, A.A., Salzberg, A., Bellen, H.J., Glover, D.M. Genes Dev. (1998) [Pubmed]
  6. NuMA: a protein involved in nuclear structure, spindle assembly, and nuclear re-formation. Cleveland, D.W. Trends Cell Biol. (1995) [Pubmed]
  7. Collapsin response mediator protein-1 and the invasion and metastasis of cancer cells. Shih, J.Y., Yang, S.C., Hong, T.M., Yuan, A., Chen, J.J., Yu, C.J., Chang, Y.L., Lee, Y.C., Peck, K., Wu, C.W., Yang, P.C. J. Natl. Cancer Inst. (2001) [Pubmed]
  8. A Bub2p-dependent spindle checkpoint pathway regulates the Dbf2p kinase in budding yeast. Fesquet, D., Fitzpatrick, P.J., Johnson, A.L., Kramer, K.M., Toyn, J.H., Johnston, L.H. EMBO J. (1999) [Pubmed]
  9. Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis. Wordeman, L., Mitchison, T.J. J. Cell Biol. (1995) [Pubmed]
  10. NuMA: an unusually long coiled-coil related protein in the mammalian nucleus. Yang, C.H., Lambie, E.J., Snyder, M. J. Cell Biol. (1992) [Pubmed]
  11. Identification of a Golgi-associated protein that undergoes mitosis dependent phosphorylation and relocation. McMorrow, I., Souter, W.E., Plopper, G., Burke, B. J. Cell Biol. (1990) [Pubmed]
  12. Element concentration changes in mitotically active and postmitotic enterocytes. An x-ray microanalysis study. Cameron, I.L., Smith, N.K., Pool, T.B. J. Cell Biol. (1979) [Pubmed]
  13. Differential interaction of splicing snRNPs with coiled bodies and interchromatin granules during mitosis and assembly of daughter cell nuclei. Ferreira, J.A., Carmo-Fonseca, M., Lamond, A.I. J. Cell Biol. (1994) [Pubmed]
  14. A MAP kinase is activated late in plant mitosis and becomes localized to the plane of cell division. Bögre, L., Calderini, O., Binarova, P., Mattauch, M., Till, S., Kiegerl, S., Jonak, C., Pollaschek, C., Barker, P., Huskisson, N.S., Hirt, H., Heberle-Bors, E. Plant Cell (1999) [Pubmed]
  15. Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells. Kaji, N., Ohashi, K., Shuin, M., Niwa, R., Uemura, T., Mizuno, K. J. Biol. Chem. (2003) [Pubmed]
  16. Antitumor drug fostriecin inhibits the mitotic entry checkpoint and protein phosphatases 1 and 2A. Roberge, M., Tudan, C., Hung, S.M., Harder, K.W., Jirik, F.R., Anderson, H. Cancer Res. (1994) [Pubmed]
  17. Sphingolipid transport in mitotic HeLa cells. Collins, R.N., Warren, G. J. Biol. Chem. (1992) [Pubmed]
  18. The positional control of mitosis and cytokinesis in higher-plant cells. Giménez-Abián, M.I., Utrilla, L., Cánovas, J.L., Giménez-Martín, G., Navarrete, M.H., De la Torre, C. Planta (1998) [Pubmed]
  19. Cell cycle regulation of chromatin binding and nuclear localization of human Cdc7-ASK kinase complex. Sato, N., Sato, M., Nakayama, M., Saitoh, R., Arai, K., Masai, H. Genes Cells (2003) [Pubmed]
  20. Localization of the mei-1 gene product of Caenorhaditis elegans, a meiotic-specific spindle component. Clark-Maguire, S., Mains, P.E. J. Cell Biol. (1994) [Pubmed]
  21. The yeast TEM1 gene, which encodes a GTP-binding protein, is involved in termination of M phase. Shirayama, M., Matsui, Y., Toh-E, A. Mol. Cell. Biol. (1994) [Pubmed]
  22. Phosphorylation and spindle pole body localization of the Cdc15p mitotic regulatory protein kinase in budding yeast. Xu, S., Huang, H.K., Kaiser, P., Latterich, M., Hunter, T. Curr. Biol. (2000) [Pubmed]
  23. Swi5 controls a novel wave of cyclin synthesis in late mitosis. Aerne, B.L., Johnson, A.L., Toyn, J.H., Johnston, L.H. Mol. Biol. Cell (1998) [Pubmed]
  24. Roles of Hof1p, Bni1p, Bnr1p, and myo1p in cytokinesis in Saccharomyces cerevisiae. Vallen, E.A., Caviston, J., Bi, E. Mol. Biol. Cell (2000) [Pubmed]
  25. Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins. Prymakowska-Bosak, M., Hock, R., Catez, F., Lim, J.H., Birger, Y., Shirakawa, H., Lee, K., Bustin, M. Mol. Cell. Biol. (2002) [Pubmed]
  26. The Saccharomyces cerevisiae CDC6 gene is transcribed at late mitosis and encodes a ATP/GTPase controlling S phase initiation. Zwerschke, W., Rottjakob, H.W., Küntzel, H. J. Biol. Chem. (1994) [Pubmed]
  27. Cell cycle differences in DNA damage-induced BRCA1 phosphorylation affect its subcellular localization. Okada, S., Ouchi, T. J. Biol. Chem. (2003) [Pubmed]
  28. Epidermal Langerhans cells undergo mitosis during the early recovery phase after ultraviolet-B irradiation. Miyauchi, S., Hashimoto, K. J. Invest. Dermatol. (1987) [Pubmed]
  29. Inhibition of tubulin polymerization in megakaryocyte cell lines leads to polyploidization which affects the metabolism of actin. Baatout, S., Chatelain, B., Staquet, P., Symann, M., Chatelain, C. Anticancer Res. (1998) [Pubmed]
WikiGenes - Universities