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Gene Review

cdc27  -  DNA polymerase delta subunit Cdc27

Schizosaccharomyces pombe 972h-

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High impact information on cdc27

  • No evidence was obtained for a cut phenotype, indicating that neither cdc1+ nor cdc27+ is required for checkpoint function. cdc1 mutant cells are supersensitive to the DNA synthesis inhibitor hydroxyurea and to the DNA damaging agent MMS, display increased frequency of mini-chromosome loss and have an extended S phase [1].
  • In this study, we describe the enzymatic properties of the Pfh1 helicase and the genetic interactions between pfh1 and cdc24, dna2, cdc27 or pol 3, all of which are involved in the Okazaki fragment metabolism [2].

Biological context of cdc27

  • Deletion of either cdc1+ or cdc27+ results in cell cycle arrest with the arrested cells having a single nucleus with 2C DNA content [1].

Other interactions of cdc27

  • In addition, we show that cdc1+ overexpression is sufficient to rescue cells carrying temperature-sensitive cdc27 alleles and that the Cdc1 and Cdc27 proteins interact in vivo and in vitro [1].


  1. The fission yeast Cdc1 protein, a homologue of the small subunit of DNA polymerase delta, binds to Pol3 and Cdc27. MacNeill, S.A., Moreno, S., Reynolds, N., Nurse, P., Fantes, P.A. EMBO J. (1996) [Pubmed]
  2. Genetic and biochemical analyses of Pfh1 DNA helicase function in fission yeast. Ryu, G.H., Tanaka, H., Kim, D.H., Kim, J.H., Bae, S.H., Kwon, Y.N., Rhee, J.S., MacNeill, S.A., Seo, Y.S. Nucleic Acids Res. (2004) [Pubmed]
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