Chemical Compound Review:
Hydrea hydroxyurea
Synonyms:
Cytodrox, Hydreia, Hydurea, Litaler, Litalir, ...
- Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. Charache, S., Terrin, M.L., Moore, R.D., Dover, G.J., Barton, F.B., Eckert, S.V., McMahon, R.P., Bonds, D.R. N. Engl. J. Med. (1995)
- Preliminary observations on the therapy of the myeloid blast phase of chronic granulocytic leukemia with plicamycin and hydroxyurea. Koller, C.A., Miller, D.M. N. Engl. J. Med. (1986)
- Hydroxyurea for patients with essential thrombocythemia and a high risk of thrombosis. Cortelazzo, S., Finazzi, G., Ruggeri, M., Vestri, O., Galli, M., Rodeghiero, F., Barbui, T. N. Engl. J. Med. (1995)
- Successful use of hydroxyurea in beta-thalassemia major. Arruda, V.R., Lima, C.S., Saad, S.T., Costa, F.F. N. Engl. J. Med. (1997)
- Hydroxyurea in essential thrombocytosis. Van Genderen, P.J., Michiels, J.J. N. Engl. J. Med. (1995)
- Centrophobism/thigmotaxis, a new role for the mushroom bodies in Drosophila. Besson, M., Martin, J.R. J. Neurobiol. (2005)
- Cell proliferation in a peripheral target is required for the induction of central neurogenesis in the leech. Becker, T.S., Bothe, G., Harley, A.R., Macagno, E.R. J. Neurobiol. (1998)
- Possible adrenal involvement in hydroxyurea toxicity defense mechanisms. Preziosi, P., Nunziata, A., Macrae, S., Ragazzoni, E., Vacca, M. Arch. Toxicol. Suppl. (1985)
- Sickle cell telemedicine and standard clinical encounters: a comparison of patient satisfaction. Woods, K.F., Kutlar, A., Johnson, J.A., Waller, J.L., Grigsby, R.K., Stachura, M.E., Rahn, D.W. Telemedicine journal : the official journal of the American Telemedicine Association. (1999)
- Hydroxyurea-associated squamous dysplasia. Sanchez-Palacios, C., Guitart, J. J. Am. Acad. Dermatol. (2004)
- Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Lisby, M., Barlow, J.H., Burgess, R.C., Rothstein, R. Cell (2004)
- Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA. Saitoh, S., Chabes, A., McDonald, W.H., Thelander, L., Yates, J.R., Russell, P. Cell (2002)
- Yph1p, an ORC-interacting protein: potential links between cell proliferation control, DNA replication, and ribosome biogenesis. Du, Y.C., Stillman, B. Cell (2002)
- Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. Rose, P.G., Bundy, B.N., Watkins, E.B., Thigpen, J.T., Deppe, G., Maiman, M.A., Clarke-Pearson, D.L., Insalaco, S. N. Engl. J. Med. (1999)
- Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Scully, R., Chen, J., Ochs, R.L., Keegan, K., Hoekstra, M., Feunteun, J., Livingston, D.M. Cell (1997)
- Hematologic remission and cytogenetic improvement induced by recombinant human interferon alpha A in chronic myelogenous leukemia. Talpaz, M., Kantarjian, H.M., McCredie, K., Trujillo, J.M., Keating, M.J., Gutterman, J.U. N. Engl. J. Med. (1986)
- Stimulation of F-cell production in patients with sickle-cell anemia treated with cytarabine or hydroxyurea. Veith, R., Galanello, R., Papayannopoulou, T., Stamatoyannopoulos, G. N. Engl. J. Med. (1985)
- Treatment of sickle cell anemia with hydroxyurea and erythropoietin. Goldberg, M.A., Brugnara, C., Dover, G.J., Schapira, L., Charache, S., Bunn, H.F. N. Engl. J. Med. (1990)
- Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication. Lori, F., Malykh, A., Cara, A., Sun, D., Weinstein, J.N., Lisziewicz, J., Gallo, R.C. Science (1994)
- Long-term suppression of HIV-1 by hydroxyurea and didanosine. Lori, F., Jessen, H., Foli, A., Lisziewicz, J., Matteo, P.S. JAMA (1997)
- Cytoplasmic pH and the regulation of the Dictyostelium cell cycle. Aerts, R.J., Durston, A.J., Moolenaar, W.H. Cell (1985)
- Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+. Saka, Y., Yanagida, M. Cell (1993)
- Spindle formation and chromatin condensation in cells blocked at interphase by mutation of a negative cell cycle control gene. Osmani, S.A., Engle, D.B., Doonan, J.H., Morris, N.R. Cell (1988)
- A B-lymphocyte-specific high-turnover protein: constitutive expression in resting B cells and induction of synthesis in proliferating cells. Rahmsdorf, H.J., Mallick, U., Ponta, H., Herrlich, P. Cell (1982)
- A washable macromolecule from Fv2rr marrow negatively regulates DNA synthesis in erythropoietic progenitor cells BFU-E. Axelrad, A.A., Croizat, H., Eskinazi, D. Cell (1981)
- Choice behavior of Drosophila facing contradictory visual cues. Tang, S., Guo, A. Science (2001)
- Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase. Elledge, S.J., Davis, R.W. Genes Dev. (1990)
- The requirement for DNA synthesis and gene expression in the generation of cytotoxicity in vitro. Nedrud, J., Touton, M., Clark, W.R. J. Exp. Med. (1975)
- Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide. Kwon, N.S., Stuehr, D.J., Nathan, C.F. J. Exp. Med. (1991)
- Radiosensitizing nucleosides. McGinn, C.J., Shewach, D.S., Lawrence, T.S. J. Natl. Cancer Inst. (1996)
- Mechanism of Hb F stimulation by S-stage compounds. In vitro studies with bone marrow cells exposed to 5-azacytidine, Ara-C, or hydroxyurea. Galanello, R., Stamatoyannopoulos, G., Papayannopoulou, T. J. Clin. Invest. (1988)
- Hydroxyurea nitrosylates and activates soluble guanylyl cyclase in human erythroid cells. Cokic, V.P., Andric, S.A., Stojilkovic, S.S., Noguchi, C.T., Schechter, A.N. Blood (2008)
- Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Sun, Z., Fay, D.S., Marini, F., Foiani, M., Stern, D.F. Genes Dev. (1996)
- Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Tibbetts, R.S., Cortez, D., Brumbaugh, K.M., Scully, R., Livingston, D., Elledge, S.J., Abraham, R.T. Genes Dev. (2000)
- The yeast Xrs2 complex functions in S phase checkpoint regulation. D'Amours, D., Jackson, S.P. Genes Dev. (2001)
- Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Chen, J., Silver, D.P., Walpita, D., Cantor, S.B., Gazdar, A.F., Tomlinson, G., Couch, F.J., Weber, B.L., Ashley, T., Livingston, D.M., Scully, R. Mol. Cell (1998)
- Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53. Tourrière, H., Versini, G., Cordón-Preciado, V., Alabert, C., Pasero, P. Mol. Cell (2005)
- Augmentation of fetal-hemoglobin production in anemic monkeys by hydroxyurea. Letvin, N.L., Linch, D.C., Beardsley, G.P., McIntyre, K.W., Nathan, D.G. N. Engl. J. Med. (1984)
- The insertion of DNA into vaccinia virus. Morgan, C. Science (1976)
- Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Kim, S.T., Xu, B., Kastan, M.B. Genes Dev. (2002)
- Hematopoietic stem cells in Friend murine leukemia virus-infected mice undergoing chemotherapy: remission and relapse of erythropoietin-independent erythropoiesis induced by hydroxyurea. Seidel, H.J., Opitz, U. J. Natl. Cancer Inst. (1979)