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Gene Review

cdc28  -  ATP-dependent RNA helicase Cdc28

Schizosaccharomyces pombe 972h-

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High impact information on cdc28

  • DNA sequence analysis indicated that cdc28+ encodes a member of the DEAH-box family of putative RNA-dependent ATPases or helicases [1].
  • The fission-yeast gene cdc28+ was originally identified in a screen for temperature-sensitive mutants that exhibit a cell-division cycle arrest and was found to be required for mitosis [1].


  1. A connection between pre-mRNA splicing and the cell cycle in fission yeast: cdc28+ is allelic with prp8+ and encodes an RNA-dependent ATPase/helicase. Lundgren, K., Allan, S., Urushiyama, S., Tani, T., Ohshima, Y., Frendewey, D., Beach, D. Mol. Biol. Cell (1996) [Pubmed]
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