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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Schizosaccharomyces


High impact information on Schizosaccharomyces

  • Based on these findings, we propose and test a model in which Sre1 and Scp1 monitor oxygen-dependent sterol synthesis as an indirect measure of oxygen supply and mediate a hypoxic response in fission yeast [6].
  • The chromodomain of mouse HP1 (and Swi6 in S. pombe) binds H3 methylated at Lys9, and methylation at this site is thought to mark and promote heterochromatin assembly [7].
  • A mutational analysis of c-Src expressed in Schizosaccharomyces pombe demonstrates that replacement of residues in the SH2-SH3 connector with glycine activates c-Src [8].
  • Extending the comparison of telomeric proteins to fission yeast, we identify S. pombe Taz1 as a TRF ortholog, indicating that TRFs are conserved at eukaryotic telomeres [9].
  • In Schizosaccharomyces pombe, the msh2- and pms1-dependent long-patch MMR system efficiently corrects small insertion/deletion loops and all base-base mismatches, except C/C [10].

Chemical compound and disease context of Schizosaccharomyces


Biological context of Schizosaccharomyces


Anatomical context of Schizosaccharomyces


Associations of Schizosaccharomyces with chemical compounds

  • Furthermore, mutation of nimT, which encodes a protein with 50% similarity to fission yeast cdc25, causes a G2 arrest and prevents tyrosine dephosphorylation of p34cdc2 but does not prevent full activation of the NIMA protein kinase [26].
  • Concerted evolution of tRNA genes: intergenic conversion among three unlinked serine tRNA genes in S. pombe [27].
  • S. pombe gene sds22+ essential for a midmitotic transition encodes a leucine-rich repeat protein that positively modulates protein phosphatase-1 [28].
  • The fission yeast wee1+ gene product is a dose-dependent, negative regulator of entry into mitosis. wee1+ encodes a protein of relative molecular mass 107,000 (Mr 107K), the C-terminal third of which has strong similarities with the serine/threonine protein kinase family [29].
  • A number of mutants of the fission yeast Schizosaccharomyces pombe, selected for their sensitivity to DNA damage caused by radiation (rad mutants) or to the DNA synthesis inhibitor hydroxyurea (hus mutants) have been classified as checkpoint mutants because they fail to arrest the cell cycle in response to DNA damage or incompletely replicated DNA [30].

Gene context of Schizosaccharomyces


Analytical, diagnostic and therapeutic context of Schizosaccharomyces


  1. Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases. Reifsnyder, C., Lowell, J., Clarke, A., Pillus, L. Nat. Genet. (1996) [Pubmed]
  2. A mouse cdc25 homolog is differentially and developmentally expressed. Kakizuka, A., Sebastian, B., Borgmeyer, U., Hermans-Borgmeyer, I., Bolado, J., Hunter, T., Hoekstra, M.F., Evans, R.M. Genes Dev. (1992) [Pubmed]
  3. rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest. Stewart, E., Chapman, C.R., Al-Khodairy, F., Carr, A.M., Enoch, T. EMBO J. (1997) [Pubmed]
  4. Schizosaccharomyces pombe map3+ encodes the putative M-factor receptor. Tanaka, K., Davey, J., Imai, Y., Yamamoto, M. Mol. Cell. Biol. (1993) [Pubmed]
  5. Prmt5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family. Rho, J., Choi, S., Seong, Y.R., Cho, W.K., Kim, S.H., Im, D.S. J. Biol. Chem. (2001) [Pubmed]
  6. SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast. Hughes, A.L., Todd, B.L., Espenshade, P.J. Cell (2005) [Pubmed]
  7. Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes. Boggs, B.A., Cheung, P., Heard, E., Spector, D.L., Chinault, A.C., Allis, C.D. Nat. Genet. (2002) [Pubmed]
  8. Dynamic coupling between the SH2 and SH3 domains of c-Src and Hck underlies their inactivation by C-terminal tyrosine phosphorylation. Young, M.A., Gonfloni, S., Superti-Furga, G., Roux, B., Kuriyan, J. Cell (2001) [Pubmed]
  9. Identification of human Rap1: implications for telomere evolution. Li, B., Oestreich, S., de Lange, T. Cell (2000) [Pubmed]
  10. Involvement of nucleotide-excision repair in msh2 pms1-independent mismatch repair. Fleck, O., Lehmann, E., Schär, P., Kohli, J. Nat. Genet. (1999) [Pubmed]
  11. Isolation of Schizosaccharomyces pombe isopentenyl diphosphate isomerase cDNA clones by complementation and synthesis of the enzyme in Escherichia coli. Hahn, F.M., Poulter, C.D. J. Biol. Chem. (1995) [Pubmed]
  12. Construction of an expression vector for the fission yeast Schizosaccharomyces pombe. Kudla, B., Persuy, M.A., Gaillardin, C., Heslot, H. Nucleic Acids Res. (1988) [Pubmed]
  13. Sequence changes in both flanking sequences of a pre-tRNA influence the cleavage specificity of RNase P. Krupp, G., Kahle, D., Vogt, T., Char, S. J. Mol. Biol. (1991) [Pubmed]
  14. The melaminophenyl arsenicals melarsoprol and melarsen oxide interfere with thiamine metabolism in the fission yeast Schizosaccharomyces pombe. Schweingruber, M.E. Antimicrob. Agents Chemother. (2004) [Pubmed]
  15. Decrease in cell surface galactose residues of Schizosaccharomyces pombe enhances its coflocculation with Pediococcus damnosus. Peng, X., Sun, J., Michiels, C., Iserentant, D., Verachtert, H. Appl. Environ. Microbiol. (2001) [Pubmed]
  16. A fission yeast B-type cyclin functioning early in the cell cycle. Bueno, A., Richardson, H., Reed, S.I., Russell, P. Cell (1991) [Pubmed]
  17. The S. pombe cdc15 gene is a key element in the reorganization of F-actin at mitosis. Fankhauser, C., Reymond, A., Cerutti, L., Utzig, S., Hofmann, K., Simanis, V. Cell (1995) [Pubmed]
  18. DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe. Uemura, T., Ohkura, H., Adachi, Y., Morino, K., Shiozaki, K., Yanagida, M. Cell (1987) [Pubmed]
  19. Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+. Draetta, G., Brizuela, L., Potashkin, J., Beach, D. Cell (1987) [Pubmed]
  20. Circular chromosome formation in a fission yeast mutant defective in two ATM homologues. Naito, T., Matsuura, A., Ishikawa, F. Nat. Genet. (1998) [Pubmed]
  21. tea1 and the microtubular cytoskeleton are important for generating global spatial order within the fission yeast cell. Mata, J., Nurse, P. Cell (1997) [Pubmed]
  22. The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Riabowol, K., Draetta, G., Brizuela, L., Vandre, D., Beach, D. Cell (1989) [Pubmed]
  23. Regulation of cell polarity by microtubules in fission yeast. Sawin, K.E., Nurse, P. J. Cell Biol. (1998) [Pubmed]
  24. Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function. Gould, K.L., Moreno, S., Owen, D.J., Sazer, S., Nurse, P. EMBO J. (1991) [Pubmed]
  25. A novel fission yeast gene, tht1+, is required for the fusion of nuclear envelopes during karyogamy. Tange, Y., Horio, T., Shimanuki, M., Ding, D.Q., Hiraoka, Y., Niwa, O. J. Cell Biol. (1998) [Pubmed]
  26. Parallel activation of the NIMA and p34cdc2 cell cycle-regulated protein kinases is required to initiate mitosis in A. nidulans. Osmani, A.H., McGuire, S.L., Osmani, S.A. Cell (1991) [Pubmed]
  27. Concerted evolution of tRNA genes: intergenic conversion among three unlinked serine tRNA genes in S. pombe. Amstutz, H., Munz, P., Heyer, W.D., Leupoid, U., Kohli, J. Cell (1985) [Pubmed]
  28. S. pombe gene sds22+ essential for a midmitotic transition encodes a leucine-rich repeat protein that positively modulates protein phosphatase-1. Ohkura, H., Yanagida, M. Cell (1991) [Pubmed]
  29. Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase. Featherstone, C., Russell, P. Nature (1991) [Pubmed]
  30. Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. Walworth, N., Davey, S., Beach, D. Nature (1993) [Pubmed]
  31. Role of a ras homolog in the life cycle of Schizosaccharomyces pombe. Fukui, Y., Kozasa, T., Kaziro, Y., Takeda, T., Yamamoto, M. Cell (1986) [Pubmed]
  32. Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA. Shinohara, A., Ogawa, H., Matsuda, Y., Ushio, N., Ikeo, K., Ogawa, T. Nat. Genet. (1993) [Pubmed]
  33. A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae. Courchesne, W.E., Kunisawa, R., Thorner, J. Cell (1989) [Pubmed]
  34. The fission yeast cut1+ gene regulates spindle pole body duplication and has homology to the budding yeast ESP1 gene. Uzawa, S., Samejima, I., Hirano, T., Tanaka, K., Yanagida, M. Cell (1990) [Pubmed]
  35. Conservation of mitotic controls in fission and budding yeasts. Russell, P., Moreno, S., Reed, S.I. Cell (1989) [Pubmed]
  36. Dimeric transfer RNA precursors in S. pombe. Mao, J., Schmidt, O., Söll, D. Cell (1980) [Pubmed]
  37. cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF. Arion, D., Meijer, L., Brizuela, L., Beach, D. Cell (1988) [Pubmed]
  38. Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating. Ottilie, S., Miller, P.J., Johnson, D.I., Creasy, C.L., Sells, M.A., Bagrodia, S., Forsburg, S.L., Chernoff, J. EMBO J. (1995) [Pubmed]
  39. An anillin homologue, Mid2p, acts during fission yeast cytokinesis to organize the septin ring and promote cell separation. Tasto, J.J., Morrell, J.L., Gould, K.L. J. Cell Biol. (2003) [Pubmed]
  40. Substitution at position 116 of Schizosaccharomyces pombe calmodulin decreases its stability under nitrogen starvation and results in a sporulation-deficient phenotype. Takeda, T., Imai, Y., Yamamoto, M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
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