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Gene Review

mcs4  -  response regulator Mcs4

Schizosaccharomyces pombe 972h-

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High impact information on mcs4

  • A mutation of mcs4+ (mitotic catastrophe suppressor) was originally isolated as a suppressor of the mitotic catastrophe phenotype of a cdc2-3w wee1-50 double mutant [1].
  • Strains carrying the mcs4 and cdc25 mutations display a synthetic osmotic lethal phenotype along with an inability to grow on minimal synthetic medium [2].
  • The mcs4 gene product displays significant sequence homology to members of the two-component system response regulator protein family [2].


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