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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

mcs4  -  response regulator Mcs4

Schizosaccharomyces pombe 972h-

 
 
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High impact information on mcs4

  • A mutation of mcs4+ (mitotic catastrophe suppressor) was originally isolated as a suppressor of the mitotic catastrophe phenotype of a cdc2-3w wee1-50 double mutant [1].
  • Strains carrying the mcs4 and cdc25 mutations display a synthetic osmotic lethal phenotype along with an inability to grow on minimal synthetic medium [2].
  • The mcs4 gene product displays significant sequence homology to members of the two-component system response regulator protein family [2].

References

  1. Mcs4 mitotic catastrophe suppressor regulates the fission yeast cell cycle through the Wik1-Wis1-Spc1 kinase cascade. Shiozaki, K., Shiozaki, M., Russell, P. Mol. Biol. Cell (1997) [Pubmed]
  2. Mcs4, a two-component system response regulator homologue, regulates the Schizosaccharomyces pombe cell cycle control. Cottarel, G. Genetics (1997) [Pubmed]
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