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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Sequence Homology

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Disease relevance of Sequence Homology


Psychiatry related information on Sequence Homology


High impact information on Sequence Homology

  • Both mu- and m-calpain are heterodimers containing an identical 28-kDa subunit and an 80-kDa subunit that shares 55-65% sequence homology between the two proteases [9].
  • Remarkably, the Ero1p active site closely resembles that of the versatile thiol oxidase module of Erv2p, a protein with no sequence homology to Ero1p [10].
  • ALMS1 is ubiquitously expressed at low levels and does not share significant sequence homology with other genes reported so far [11].
  • APC contains sequences homologous to the phosphorylated region of cadherin, and is likely to bind similarly [12].
  • Mutations in SGS1 increased the rate of accumulating gross chromosomal rearrangements (GCRs), including translocations and deletions containing extended regions of imperfect homology at their breakpoints. sgs1 mutations also increased the rate of recombination between DNA sequences that had 91% sequence homology [13].

Chemical compound and disease context of Sequence Homology


Biological context of Sequence Homology


Anatomical context of Sequence Homology

  • The X, Y and ovalbumin genes, which are found within a 40 kb region of the chicken genome, are all expressed in oviduct under steroid hormone control, and share some sequence homologies [24].
  • Inspection of the 171-amino acid sequence reveals a signal peptide, a 79-amino acid extracellular domain, one transmembrane region and a 44-amino acid intracellular domain which show no sequence homology with members of the T-cell receptor/immunoglobulin/MHC multi-gene family [25].
  • The yeast PtdIns-TP, SEC14p (ref. 6), which has no sequence homology to mammalian PtdIns-TP (refs 7,8), was able to substitute for the mammalian PtdIns-TP in secretory vesicle formation [26].
  • Urogastrone, a polypeptide bearing anti-gastric secretory activity isolated from human urine, which is presumably synthesized in submandibular and Brunner's glands, shares extensive sequence homology (70%) with EGF and may represent the human EGF equivalent [27].
  • This protein, hepatocyte nuclear factor 1 (HNF1), also interacts with homologous sequences required for optimal promoter function of the genes for the alpha chain of fibrinogen and alpha 1-antitrypsin [28].

Associations of Sequence Homology with chemical compounds


Gene context of Sequence Homology


Analytical, diagnostic and therapeutic context of Sequence Homology


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