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MeSH Review

Sequence Homology

 
 
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Disease relevance of Sequence Homology

 

Psychiatry related information on Sequence Homology

 

High impact information on Sequence Homology

  • Both mu- and m-calpain are heterodimers containing an identical 28-kDa subunit and an 80-kDa subunit that shares 55-65% sequence homology between the two proteases [9].
  • Remarkably, the Ero1p active site closely resembles that of the versatile thiol oxidase module of Erv2p, a protein with no sequence homology to Ero1p [10].
  • ALMS1 is ubiquitously expressed at low levels and does not share significant sequence homology with other genes reported so far [11].
  • APC contains sequences homologous to the phosphorylated region of cadherin, and is likely to bind similarly [12].
  • Mutations in SGS1 increased the rate of accumulating gross chromosomal rearrangements (GCRs), including translocations and deletions containing extended regions of imperfect homology at their breakpoints. sgs1 mutations also increased the rate of recombination between DNA sequences that had 91% sequence homology [13].
 

Chemical compound and disease context of Sequence Homology

 

Biological context of Sequence Homology

 

Anatomical context of Sequence Homology

  • The X, Y and ovalbumin genes, which are found within a 40 kb region of the chicken genome, are all expressed in oviduct under steroid hormone control, and share some sequence homologies [24].
  • Inspection of the 171-amino acid sequence reveals a signal peptide, a 79-amino acid extracellular domain, one transmembrane region and a 44-amino acid intracellular domain which show no sequence homology with members of the T-cell receptor/immunoglobulin/MHC multi-gene family [25].
  • The yeast PtdIns-TP, SEC14p (ref. 6), which has no sequence homology to mammalian PtdIns-TP (refs 7,8), was able to substitute for the mammalian PtdIns-TP in secretory vesicle formation [26].
  • Urogastrone, a polypeptide bearing anti-gastric secretory activity isolated from human urine, which is presumably synthesized in submandibular and Brunner's glands, shares extensive sequence homology (70%) with EGF and may represent the human EGF equivalent [27].
  • This protein, hepatocyte nuclear factor 1 (HNF1), also interacts with homologous sequences required for optimal promoter function of the genes for the alpha chain of fibrinogen and alpha 1-antitrypsin [28].
 

Associations of Sequence Homology with chemical compounds

 

Gene context of Sequence Homology

 

Analytical, diagnostic and therapeutic context of Sequence Homology

References

  1. N4 virion RNA polymerase sites of transcription initiation. Haynes, L.L., Rothman-Denes, L.B. Cell (1985) [Pubmed]
  2. CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. Smith, C.A., Gruss, H.J., Davis, T., Anderson, D., Farrah, T., Baker, E., Sutherland, G.R., Brannan, C.I., Copeland, N.G., Jenkins, N.A. Cell (1993) [Pubmed]
  3. Generation of BALB-MuSV and Ha-MuSC by type C virus transduction of homologous transforming genes from different species. Andersen, P.R., Devare, S.G., Tronick, S.R., Ellis, R.W., Aaronson, S.A., Scolnick, E.M. Cell (1981) [Pubmed]
  4. Telomere regions in Drosophila share complex DNA sequences with pericentric heterochromatin. Young, B.S., Pession, A., Traverse, K.L., French, C., Pardue, M.L. Cell (1983) [Pubmed]
  5. A new class of uracil-DNA glycosylases related to human thymine-DNA glycosylase. Gallinari, P., Jiricny, J. Nature (1996) [Pubmed]
  6. Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophrenia. Karlsson, H., Bachmann, S., Schröder, J., McArthur, J., Torrey, E.F., Yolken, R.H. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  7. Kunitz-type protease inhibitor found in rat mast cells. Purification, properties, and amino acid sequence. Kido, H., Yokogoshi, Y., Katunuma, N. J. Biol. Chem. (1988) [Pubmed]
  8. Variable regions of two murine antibodies that bind the SLE associated 16/6 idiotype. Waisman, A., Ruiz, P.J., Mozes, E. Lupus (1996) [Pubmed]
  9. The calpain system. Goll, D.E., Thompson, V.F., Li, H., Wei, W., Cong, J. Physiol. Rev. (2003) [Pubmed]
  10. Structure of Ero1p, source of disulfide bonds for oxidative protein folding in the cell. Gross, E., Kastner, D.B., Kaiser, C.A., Fass, D. Cell (2004) [Pubmed]
  11. Mutations in ALMS1 cause obesity, type 2 diabetes and neurosensory degeneration in Alström syndrome. Collin, G.B., Marshall, J.D., Ikeda, A., So, W.V., Russell-Eggitt, I., Maffei, P., Beck, S., Boerkoel, C.F., Sicolo, N., Martin, M., Nishina, P.M., Naggert, J.K. Nat. Genet. (2002) [Pubmed]
  12. The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. Huber, A.H., Weis, W.I. Cell (2001) [Pubmed]
  13. SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination. Myung, K., Datta, A., Chen, C., Kolodner, R.D. Nat. Genet. (2001) [Pubmed]
  14. Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma. Dejean, A., Bougueleret, L., Grzeschik, K.H., Tiollais, P. Nature (1986) [Pubmed]
  15. Antifibrillarin autoantibodies present in systemic sclerosis and other connective tissue diseases interact with similar epitopes. Kasturi, K.N., Hatakeyama, A., Spiera, H., Bona, C.A. J. Exp. Med. (1995) [Pubmed]
  16. Bacteriophage T4-induced anticodon-loop nuclease detected in a host strain restrictive to RNA ligase mutants. David, M., Borasio, G.D., Kaufmann, G. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  17. Camphor hydroxylase of Pseudomonas putida: vestiges of sequence homology in cytochrome P-450CAM, putidaredoxin, and related proteins. Dus, K.M. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  18. RecA.oligonucleotide filaments bind in the minor groove of double-stranded DNA. Baliga, R., Singleton, J.W., Dervan, P.B. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  19. DNA sequence analysis of the transposon Tn3: three genes and three sites involved in transposition of Tn3. Heffron, F., McCarthy, B.J., Ohtsubo, H., Ohtsubo, E. Cell (1979) [Pubmed]
  20. Identification of the familial cylindromatosis tumour-suppressor gene. Bignell, G.R., Warren, W., Seal, S., Takahashi, M., Rapley, E., Barfoot, R., Green, H., Brown, C., Biggs, P.J., Lakhani, S.R., Jones, C., Hansen, J., Blair, E., Hofmann, B., Siebert, R., Turner, G., Evans, D.G., Schrander-Stumpel, C., Beemer, F.A., van Den Ouweland, A., Halley, D., Delpech, B., Cleveland, M.G., Leigh, I., Leisti, J., Rasmussen, S. Nat. Genet. (2000) [Pubmed]
  21. Analysis of a drosophila tRNA gene cluster: two tRNALeu genes contain intervening sequences. Robinson, R.R., Davidson, N. Cell (1981) [Pubmed]
  22. Sequence analysis, cellular localization, and expression of a neuroretina adhesion and cell survival molecule. Berman, P., Gray, P., Chen, E., Keyser, K., Ehrlich, D., Karten, H., LaCorbiere, M., Esch, F., Schubert, D. Cell (1987) [Pubmed]
  23. Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbB protein. Kris, R.M., Lax, I., Gullick, W., Waterfield, M.D., Ullrich, A., Fridkin, M., Schlessinger, J. Cell (1985) [Pubmed]
  24. The ovalbumin gene family: structure of the X gene and evolution of duplicated split genes. Heilig, R., Perrin, F., Gannon, F., Mandel, J.L., Chambon, P. Cell (1980) [Pubmed]
  25. Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex. van den Elsen, P., Shepley, B.A., Borst, J., Coligan, J.E., Markham, A.F., Orkin, S., Terhorst, C. Nature (1984) [Pubmed]
  26. A role for phosphatidylinositol transfer protein in secretory vesicle formation. Ohashi, M., Jan de Vries, K., Frank, R., Snoek, G., Bankaitis, V., Wirtz, K., Huttner, W.B. Nature (1995) [Pubmed]
  27. Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor. Gray, A., Dull, T.J., Ullrich, A. Nature (1983) [Pubmed]
  28. Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters. Courtois, G., Morgan, J.G., Campbell, L.A., Fourel, G., Crabtree, G.R. Science (1987) [Pubmed]
  29. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Stambolic, V., Suzuki, A., de la Pompa, J.L., Brothers, G.M., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J.M., Siderovski, D.P., Mak, T.W. Cell (1998) [Pubmed]
  30. Solution structure of BID, an intracellular amplifier of apoptotic signaling. Chou, J.J., Li, H., Salvesen, G.S., Yuan, J., Wagner, G. Cell (1999) [Pubmed]
  31. Intron/exon structure of the chicken pyruvate kinase gene. Lonberg, N., Gilbert, W. Cell (1985) [Pubmed]
  32. Maize mitochondrial DNA contains a sequence homologous to the ribulose-1,5-bisphosphate carboxylase large subunit gene of chloroplast DNA. Lonsdale, D.M., Hodge, T.P., Howe, C.J., Stern, D.B. Cell (1983) [Pubmed]
  33. Evolution of immunoglobulin V genes: evidence indicating that recently duplicated human V kappa sequences have diverged by gene conversion. Bentley, D.L., Rabbitts, T.H. Cell (1983) [Pubmed]
  34. Role of the p53-homologue p73 in E2F1-induced apoptosis. Stiewe, T., Pützer, B.M. Nat. Genet. (2000) [Pubmed]
  35. BRCA1 is secreted and exhibits properties of a granin. Jensen, R.A., Thompson, M.E., Jetton, T.L., Szabo, C.I., van der Meer, R., Helou, B., Tronick, S.R., Page, D.L., King, M.C., Holt, J.T. Nat. Genet. (1996) [Pubmed]
  36. Mutations in a new gene encoding a thiamine transporter cause thiamine-responsive megaloblastic anaemia syndrome. Diaz, G.A., Banikazemi, M., Oishi, K., Desnick, R.J., Gelb, B.D. Nat. Genet. (1999) [Pubmed]
  37. Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Grawunder, U., Wilm, M., Wu, X., Kulesza, P., Wilson, T.E., Mann, M., Lieber, M.R. Nature (1997) [Pubmed]
  38. A retinoblastoma-binding protein related to a negative regulator of Ras in yeast. Qian, Y.W., Wang, Y.C., Hollingsworth, R.E., Jones, D., Ling, N., Lee, E.Y. Nature (1993) [Pubmed]
  39. Identification of maize histone deacetylase HD2 as an acidic nucleolar phosphoprotein. Lusser, A., Brosch, G., Loidl, A., Haas, H., Loidl, P. Science (1997) [Pubmed]
  40. Anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme. Lüdemann, J., Utecht, B., Gross, W.L. J. Exp. Med. (1990) [Pubmed]
  41. Characterization and biological properties of a new staphylococcal exotoxin. Ren, K., Bannan, J.D., Pancholi, V., Cheung, A.L., Robbins, J.C., Fischetti, V.A., Zabriskie, J.B. J. Exp. Med. (1994) [Pubmed]
  42. NF-kappa B and related proteins: Rel/dorsal homologies meet ankyrin-like repeats. Blank, V., Kourilsky, P., Israël, A. Trends Biochem. Sci. (1992) [Pubmed]
  43. Molecular cloning, primary structure and expression of the human X linked A1S9 gene cDNA which complements the ts A1S9 mouse L cell defect in DNA replication. Zacksenhaus, E., Sheinin, R. EMBO J. (1990) [Pubmed]
 
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