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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

aps1  -  diadenosine 5',5'''-p1,p6-hexaphosphate...

Schizosaccharomyces pombe 972h-

 
 
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Disease relevance of SPAC13G6.14

  • The gene, designated aps1, has been cloned and the protein has been purified from Escherichia coli with a yield of 10 mg of Aps1/L of culture [1].
 

High impact information on SPAC13G6.14

  • Disruption of aps1 resulted in a 52% decrease in Ap(6)A hydrolase activity in vitro, no detectable change in the intracellular Ap(5)A concentration, and 3-fold increased intracellular concentrations of PP-Ins P(5) and [PP](x)-InsP(x) [2].

References

  1. Schizosaccharomyces pombe Aps1, a diadenosine 5',5' "-P1, P6-hexaphosphate hydrolase that is a member of the nudix (MutT) family of hydrolases: cloning of the gene and characterization of the purified enzyme. Ingram, S.W., Stratemann, S.A., Barnes, L.D. Biochemistry (1999) [Pubmed]
  2. Disruption and overexpression of the Schizosaccharomyces pombe aps1 gene, and effects on growth rate, morphology and intracellular diadenosine 5',5"'-P1,P5-pentaphosphate and diphosphoinositol polyphosphate concentrations. Ingram, S.W., Safrany, S.T., Barnes, L.D. Biochem. J. (2003) [Pubmed]
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