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Chemical Compound Review

AppppppA     [(2R,3S,4R,5R)-5-(6- aminopurin-9-yl)-3,4...

Synonyms: Ap6A, CHEBI:63689, HMDB01282, KST-1A6247, LS-15142, ...
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Disease relevance of Diadenosine hexaphosphate


High impact information on Diadenosine hexaphosphate


Biological context of Diadenosine hexaphosphate


Anatomical context of Diadenosine hexaphosphate


Gene context of Diadenosine hexaphosphate

  • More distal to the Nudt motif, H91L and F84Y mutations substantially decreased the rate of Ap(6)A and (PP)(2)-InsP(4) metabolism (by 71 and 96%), yet PP-InsP(5) hydrolysis was only mildly reduced (by 30%); these results indicate substrate-specific roles for His(91) and Phe(84) [4].
  • Disruption of aps1 resulted in a 52% decrease in Ap(6)A hydrolase activity in vitro, no detectable change in the intracellular Ap(5)A concentration, and 3-fold increased intracellular concentrations of PP-Ins P(5) and [PP](x)-InsP(x) [12].

Analytical, diagnostic and therapeutic context of Diadenosine hexaphosphate


  1. The Nudix hydrolase Ndx1 from Thermus thermophilus HB8 is a diadenosine hexaphosphate hydrolase with a novel activity. Iwai, T., Kuramitsu, S., Masui, R. J. Biol. Chem. (2004) [Pubmed]
  2. Acyl-CoA synthetase catalyzes the synthesis of diadenosine hexaphosphate (Ap6A). Fontes, R., Günther Sillero, M.A., Sillero, A. Biochimie (1999) [Pubmed]
  3. Diadenosine phosphates and the physiological control of blood pressure. Schlüter, H., Offers, E., Brüggemann, G., van der Giet, M., Tepel, M., Nordhoff, E., Karas, M., Spieker, C., Witzel, H., Zidek, W. Nature (1994) [Pubmed]
  4. Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates. Yang, X., Safrany, S.T., Shears, S.B. J. Biol. Chem. (1999) [Pubmed]
  5. Identification of diadenosine hexaphosphate in human erythrocytes. Luo, J., Jankowski, J., Tepel, M., von Der Giet, M., Zidek, W., Schlüter, H. Hypertension (1999) [Pubmed]
  6. The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein. Safrany, S.T., Ingram, S.W., Cartwright, J.L., Falck, J.R., McLennan, A.G., Barnes, L.D., Shears, S.B. J. Biol. Chem. (1999) [Pubmed]
  7. Diadenosine polyphosphate-induced increase in cytosolic free calcium in vascular smooth muscle cells. Tepel, M., Bachmann, J., Schluter, H., Zidek, W. J. Hypertens. (1995) [Pubmed]
  8. Characterization and quantification of diadenosine hexaphosphate in chromaffin cells: granular storage and secretagogue-induced release. Pintor, J., Rotllán, P., Torres, M., Miras-Portugal, M.T. Anal. Biochem. (1992) [Pubmed]
  9. Effects of dinucleoside polyphosphates on regulation of coronary vascular tone. van der Giet, M., Schmidt, S., Tölle, M., Jankowski, J., Schlüter, H., Zidek, W., Tepel, M. Eur. J. Pharmacol. (2002) [Pubmed]
  10. Effect of diadenosine phosphates on human umbilical vessels: novel platelet-derived vasoconstrictors. Davies, G., MacAllister, R.J., Bogle, R.G., Vallance, P. British journal of clinical pharmacology. (1995) [Pubmed]
  11. Dinucleoside polyphosphates and their interaction with other nucleotide signaling pathways. Delicado, E.G., Miras-Portugal, M.T., Carrasquero, L.M., León, D., Pérez-Sen, R., Gualix, J. Pflugers Arch. (2006) [Pubmed]
  12. Disruption and overexpression of the Schizosaccharomyces pombe aps1 gene, and effects on growth rate, morphology and intracellular diadenosine 5',5"'-P1,P5-pentaphosphate and diphosphoinositol polyphosphate concentrations. Ingram, S.W., Safrany, S.T., Barnes, L.D. Biochem. J. (2003) [Pubmed]
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