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Gene Review:

ALS5 - amyotrophic lateral sclerosis 5

Homo sapiens

Sheppard, D.C. et al., Hentati, A. et al., Cox, P.R. et al.

Cox, Siddique, Zoghbi, Hentati, Ouahchi, Pericak-Vance, Nijhawan, Ahmad, Yang, Rimmler, Hung, Schlotter, Ahmed, Ben Hamida, Hentati, Siddique, Sheppard, Yeaman, Welch, Phan, Fu, Ibrahim, Filler, Zhang, Waring, Edwards,

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High impact information on ALS5

Using chimeric Als5p-Als6p constructs, the regions mediating substrate-specific adherence were localized to the N-terminal domains in Als proteins [1].
Two members of the C. albicans Als protein family (Als1p and Als5p) have been found to mediate adherence; however, the functions of other members of this family are unknown [1].
We now report linkage of a more-common form of RFALS to chromosome 15q15-q22 markers (ALS5) and show further genetic locus heterogeneity in RFALS [2].
Sequence analysis of TMOD2 revealed no mutations or polymorphisms in ALS5 patients or controls [3].

References

Functional and structural diversity in the Als protein family of Candida albicans. Sheppard, D.C., Yeaman, M.R., Welch, W.H., Phan, Q.T., Fu, Y., Ibrahim, A.S., Filler, S.G., Zhang, M., Waring, A.J., Edwards, J.E. J. Biol. Chem. (2004) [Pubmed]
Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers. Hentati, A., Ouahchi, K., Pericak-Vance, M.A., Nijhawan, D., Ahmad, A., Yang, Y., Rimmler, J., Hung, W., Schlotter, B., Ahmed, A., Ben Hamida, M., Hentati, F., Siddique, T. Neurogenetics (1998) [Pubmed]
Genomic organization of Tropomodulins 2 and 4 and unusual intergenic and intraexonic splicing of YL-1 and Tropomodulin 4. Cox, P.R., Siddique, T., Zoghbi, H.Y. BMC Genomics (2001) [Pubmed]

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