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Gene Review

HECTD1  -  HECT domain containing E3 ubiquitin...

Homo sapiens

Synonyms: E3 ligase for inhibin receptor, E3 ubiquitin-protein ligase HECTD1, EULIR, HECT domain-containing protein 1, KIAA1131
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High impact information on HECTD1

  • Expression of Nedd4, a HECT domain-containing ubiquitin ligase, induces the disappearance of VEGF-R2 in cells, suggesting that Nedd4 is involved in VEGF-R2 degradation [1].
  • This is a HECT domain-containing ligase that was originally identified through its involvement in the E6-mediated degradation of the cellular tumour suppressor protein p53 [2].
  • The number of predicted E3s in the mammalian genome is exceeding 400 and is represented by two major subfamilies: HECT domain-containing E3s and RING finger-type E3s [3].


  1. Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation. Murdaca, J., Treins, C., Monthouël-Kartmann, M.N., Pontier-Bres, R., Kumar, S., Van Obberghen, E., Giorgetti-Peraldi, S. J. Biol. Chem. (2004) [Pubmed]
  2. Inhibition of E6-induced degradation of its cellular substrates by novel blocking peptides. Sterlinko Grm, H., Weber, M., Elston, R., McIntosh, P., Griffin, H., Banks, L., Doorbar, J. J. Mol. Biol. (2004) [Pubmed]
  3. Methods for the functional genomic analysis of ubiquitin ligases. Li, W., Chanda, S.K., Micik, I., Joazeiro, C.A. Meth. Enzymol. (2005) [Pubmed]
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