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Gene Review:

Olfr53 - olfactory receptor 53

Mus musculus

Synonyms: GA_x6K02T2PBJ9-42798103-42799038, IE12, MOR253-5

Adib-Conquy, M. et al., Adib-Conquy, M. et al.

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High impact information on Olfr53

In addition, we evaluated the impact of the proline residues in the HCDR3 of IE12 on its activity, because they are known to restrict backbone flexibility [1].
The nucleotide sequences of the variable region of the heavy and light chains of IE12 were determined, and compared to those of another mAb already described in the literature [2].

Analytical, diagnostic and therapeutic context of Olfr53

Site-directed mutagenesis modified the HCDR3 of IE12 compared to that of the natural antibody and the resulting effects on its reactivity were analyzed [1].

References

Effect of amino acid substitutions in the heavy chain CDR3 of an autoantibody on its reactivity. Adib-Conquy, M., Gilbert, M., Avrameas, S. Int. Immunol. (1998) [Pubmed]
Reactivity and structure of a mouse anti-F(ab')2 IgM. Comparison of its variable region sequences with those of a structurally close polyreactive natural IgM. Adib-Conquy, M., Gilbert, M., Christodoulou, C., Avrameas, S. Mol. Immunol. (1994) [Pubmed]

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