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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

KCNG2  -  potassium channel, voltage gated modifier...

Homo sapiens

Synonyms: Cardiac potassium channel subunit, KCNF2, KV6.2, Kv6.2, Potassium voltage-gated channel subfamily G member 2, ...
 
 
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High impact information on KCNG2

  • The most dramatic change was the >10-fold downregulation of KCNG2 and KCNV2, two electrically silent gamma-subunits that form heterotetramers with functional K(V) channel alpha-subunits (e.g., KCNB1-2) [1].
  • RESULTS: The index case displayed a novel mutation in a cardiac potassium channel subunit gene, KCNQ1, which is likely to prolong cardiac membrane depolarization and increase susceptibility to long QT intervals [2].

References

  1. Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells. Fantozzi, I., Platoshyn, O., Wong, A.H., Zhang, S., Remillard, C.V., Furtado, M.R., Petrauskene, O.V., Yuan, J.X. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
  2. QT interval prolongation associated with sibutramine treatment. Harrison-Woolrych, M., Clark, D.W., Hill, G.R., Rees, M.I., Skinner, J.R. British journal of clinical pharmacology. (2006) [Pubmed]
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