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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Down-Regulation

 
 
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Disease relevance of Down-Regulation

 

Psychiatry related information on Down-Regulation

 

High impact information on Down-Regulation

 

Chemical compound and disease context of Down-Regulation

 

Biological context of Down-Regulation

  • Phosphorylation and downregulation of Yan is facilitated by a protein called Mae [21].
  • Therefore, Drosophila cyclin E, which forms a complex with the Dmcdc2c kinase, controls progression through S phase and its down-regulation limits embryonic proliferation [22].
  • We propose that ESCRT-I represents a conserved component of the endosomal sorting machinery that functions in both yeast and mammalian cells to couple ubiquitin modification to protein sorting and receptor downregulation in the MVB pathway [23].
  • The downregulation of PS1 in these U937 transfectants results in reduced growth with an increased fraction of the cells in apoptosis [24].
  • Whereas the down-regulation of myc seems to be an early event of F9 differentiation occurring within the first 24 h, the post-transcriptional regulation of p53 occurs at a later stage (two to three days), possibly as a consequence of cell cycle changes [25].
 

Anatomical context of Down-Regulation

 

Associations of Down-Regulation with chemical compounds

  • We have located the distal boundary of the tyrosine kinase domain of the EGF receptor and have identified a distinct sequence in the C' terminus required for EGF-dependent receptor internalization, leading to receptor down-regulation and degradation [31].
  • Conversely, down-regulation of NCX by siRNA compromised neuronal Ca2+ handling, transforming the Ca2+ transient elicited by non-excitotoxic glutamate concentrations into a lethal Ca2+overload [32].
  • Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells [33].
  • Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage [34].
  • A mutant form of the SIVmac239 Nef, which contains changes in a putative SH3-binding domain (amino acids 104 and 107 have been changed from PxxP to AxxA), does not associate with cellular serine/threonine kinases, but is fully active in CD4 downregulation and associates with the cellular tyrosine kinase Src [35].
 

Gene context of Down-Regulation

 

Analytical, diagnostic and therapeutic context of Down-Regulation

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