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Gene Review

FBXO6  -  F-box protein 6

Homo sapiens

Synonyms: F-box only protein 6, F-box protein that recognizes sugar chains 2, F-box/G-domain protein 2, FBG2, FBS2, ...
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Disease relevance of FBXO6

  • Expression of FBG2 was strongly inhibited in hepatoma cells by okadaic acid [1].

High impact information on FBXO6

  • Expression of rat FBG2 gene was found related to differentiation/proliferation status of hepatocytes [1].
  • Further analysis using synthetic oligodeoxyribonucleotides and GER defined a binding region of 30 bp (AvaI-AvaII) from -503 to -472 that partially overlaps with a region known to bind fos promoter binding site 2 (FBS2) [2].


  1. A new subfamily of structurally related human F-box proteins. Ilyin, G.P., Sérandour, A.L., Pigeon, C., Rialland, M., Glaise, D., Guguen-Guillouzo, C. Gene (2002) [Pubmed]
  2. Characterization of a 142-bp fragment of the murine c-fos oncogene promoter upstream of the SIF-binding element. Lavrovsky, Y., Abraham, N.G., Levere, R.D., Lavrovsky, V., Schwartzman, M.L., Kappas, A. Gene (1994) [Pubmed]
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