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Gene Review

angM  -  ORF1

Vibrio anguillarum 775

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High impact information on angM

  • The mutations in angM that affected anguibactin production also resulted in a dramatic attenuation of the virulence of V. anguillarum 775, highlighting the importance of this gene in the establishment of a septicemic infection in the vertebrate host [1].
  • The authors have identified the genes involved in 2,3-dihydroxybenzoic acid (DHBA) biosynthesis (vabA, vabB and vabC) and activation (vabE), and a gene (vabF) encoding a non-ribosomal peptide synthetase, which is putatively involved in the assembly of the siderophore components [2].

References

  1. A nonribosomal peptide synthetase with a novel domain organization is essential for siderophore biosynthesis in Vibrio anguillarum. Di Lorenzo, M., Poppelaars, S., Stork, M., Nagasawa, M., Tolmasky, M.E., Crosa, J.H. J. Bacteriol. (2004) [Pubmed]
  2. A gene cluster involved in the biosynthesis of vanchrobactin, a chromosome-encoded siderophore produced by Vibrio anguillarum. Balado, M., Osorio, C.R., Lemos, M.L. Microbiology (Reading, Engl.) (2006) [Pubmed]
 
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