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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Virulence


Psychiatry related information on Virulence


High impact information on Virulence


Chemical compound and disease context of Virulence


Biological context of Virulence


Anatomical context of Virulence

  • Furthermore, disruption of INT1 in C. albicans suppressed hyphal growth, adhesion to epithelial cells, and virulence in mice [21].
  • Upon contact with the eukaryotic cell, Yersinia pseudotuberculosis increased the rate of transcription of virulence genes (yop), as determined by in situ monitoring of light emission from individual bacteria expressing luciferase under the control of the yopE promoter [22].
  • One virulence factor, YopJ, is essential for the death of infected macrophages and can block host proinflammatory responses by inhibiting both the nuclear factor kappaB (NF-kappaB) and mitogen-activated protein kinase pathways, which might be important for evasion of the host immune response and aid in establishing a systemic infection [23].
  • To understand the role of VAD1 in virulence, a functional genomics approach was used to identify 3 additional virulence determinants dependent on VAD1: PCK1, TUF1, and MPF3, involved in gluconeogenesis, mitochondrial protein synthesis, and cell wall integrity, respectively [24].
  • Interestingly, the Deltaapp1 mutant strain showed a decreased virulence in mice deficient for complement C5 (A/Jcr), but it was hypervirulent in mice deficient for T and NK cells (Tgepsilon26) [25].

Associations of Virulence with chemical compounds


Gene context of Virulence

  • Our findings uncover a pathogenetic mechanism in which a host response to tissue injury-syndecan-1 shedding-is exploited to enhance microbial virulence apparently by modulating host defences [30].
  • One of these is lom, the product of which is found in the bacterial outer membrane, and is homologous to virulence proteins of two other enterobacterial genera [16].
  • Additionally, the gpa1 mutant strain failed to induce two well-established virulence factors-melanin synthesis, in response to glucose starvation; and capsule production, in response to iron limitation [20].
  • Deletion of the gammaHV68 RCA protein decreased virulence during acute CNS infection, and this attenuation was specifically reversed by deletion of host C3 [31].
  • Arabidopsis RIN4 is a key bacterial virulence target that is guarded by the resistance (R) protein RPM1 [32].

Analytical, diagnostic and therapeutic context of Virulence


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  10. Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells. Kenny, B., DeVinney, R., Stein, M., Reinscheid, D.J., Frey, E.A., Finlay, B.B. Cell (1997) [Pubmed]
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  20. Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP. Alspaugh, J.A., Perfect, J.R., Heitman, J. Genes Dev. (1997) [Pubmed]
  21. Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INT1. Gale, C.A., Bendel, C.M., McClellan, M., Hauser, M., Becker, J.M., Berman, J., Hostetter, M.K. Science (1998) [Pubmed]
  22. Modulation of virulence factor expression by pathogen target cell contact. Pettersson, J., Nordfelth, R., Dubinina, E., Bergman, T., Gustafsson, M., Magnusson, K.E., Wolf-Watz, H. Science (1996) [Pubmed]
  23. Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-kappa B activation. Zhou, H., Monack, D.M., Kayagaki, N., Wertz, I., Yin, J., Wolf, B., Dixit, V.M. J. Exp. Med. (2005) [Pubmed]
  24. The DEAD-box RNA helicase Vad1 regulates multiple virulence-associated genes in Cryptococcus neoformans. Panepinto, J., Liu, L., Ramos, J., Zhu, X., Valyi-Nagy, T., Eksi, S., Fu, J., Jaffe, H.A., Wickes, B., Williamson, P.R. J. Clin. Invest. (2005) [Pubmed]
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