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Gene Review

ctRNA  -  miscRNA

Streptococcus thermophilus

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High impact information on ctRNA

  • A DNA region that can be transcribed into a small RNA (ctRNA) complementary to the leader segment of the rep (ORF1) mRNA is proposed to be involved in the control of plasmid replication [1].
  • In vitro synthesis of this ctRNA was observed, and this constitutes the first report on the existence of such antisense RNAs, likely acting as regulatory elements, in S. thermophilus plasmids [1].


  1. Structural and functional analysis of pt38, a 2.9kb plasmid of Streptococcus thermophilus yogurt strain. Petrova, P., Miteva, V., Ruiz-Masó, J.A., del Solar, G. Plasmid (2003) [Pubmed]
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