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Gene Review

SNORA70  -  small nucleolar RNA, H/ACA box 70

Homo sapiens

Synonyms: DXS648E, RNU70, U70
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High impact information on SNORA70

  • Replacing Mg2+ with Mn2+ causes broadening of certain imino proton peaks in the NMR spectrum, indicating a specific divalent metal ion binding site in the vicinity of the major identity element of the duplex (G3-U70) that is required for its recognition by the Ala-tRNA synthetase [1].
  • Plasma phenylalanine was significantly higher with the U70 diet at 2300 than with the other three diets [2].
  • Lysine was significantly higher at 0700 with the U70 diet than with the other three diets [2].
  • Only plasma concentrations of alanine changed during the day, dropping significantly (P<0.05) at 2300 and 0300 with the U70 diet [2].


  1. The 3'-terminal end (NCCA) of tRNA determines the structure and stability of the aminoacyl acceptor stem. Limmer, S., Hofmann, H.P., Ott, G., Sprinzl, M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. Neutral and basic amino acid concentrations in plasma during the day in subjects fed with two model rural and two model urban Mexican diets. Tovar, A.R., Ascencio, C., Torres, N., Gómez, E., Bourges, H. Am. J. Clin. Nutr. (1996) [Pubmed]
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