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Gene Review

SNORA64  -  small nucleolar RNA, H/ACA box 64

Homo sapiens

Synonyms: RNU64, U64
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High impact information on SNORA64

  • In this study we have characterized nine novel human ACA snoRNAs (U64-U72) [1].
  • Our analysis of U17, U64 and U65 has revealed that disruption of either of the conserved sequence elements, Box H or Box ACA, eliminates nucleolar localization [2].
  • Human mitochondrial (mt) tRNA(Lys) deviates from this principle and folds into various inactive conformations, due to the absence of the post-transcriptional modification m(1)A9 which hinders base-pairing with U64 in the native tRNA [3].


  1. The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation. Ganot, P., Caizergues-Ferrer, M., Kiss, T. Genes Dev. (1997) [Pubmed]
  2. Nucleolar localization signals of box H/ACA small nucleolar RNAs. Narayanan, A., Lukowiak, A., Jády, B.E., Dragon, F., Kiss, T., Terns, R.M., Terns, M.P. EMBO J. (1999) [Pubmed]
  3. Aminoacylation properties of pathology-related human mitochondrial tRNA(Lys) variants. Sissler, M., Helm, M., Frugier, M., Giege, R., Florentz, C. RNA (2004) [Pubmed]
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