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MeSH Review

Conserved Sequence

 
 
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Disease relevance of Conserved Sequence

 

High impact information on Conserved Sequence

  • Finally, components of both the APC and the SCF E3 ubiquitin-ligase complex contain several conserved sequence motifs, including WD-40 repeats and cullin homology domains, which suggest that both complexes may use a similar mechanism for substrate ubiquitination [6].
  • MLH3 is more similar to mismatch repair proteins from yeast, plants, worms and bacteria than to any known mammalian protein, suggesting that its conserved sequence may confer unique functions in mice and humans [7].
  • One face of the complex exposes the sequence-conserved phosphate-binding region on Cks and the ATP-binding site on CDK2, suggesting that CKs may target CDK2 to other phosphoproteins during the cell cycle [8].
  • Ugi binds the sequence-conserved DNA-binding groove of UDG via shape and electrostatic complementarity, specific charged hydrogen bonds, and hydrophobic packing enveloping Leu-272 from a protruding UDG loop [9].
  • The KH domain is an evolutionarily conserved sequence motif present in many RNA-binding proteins, including the pre-mRNA-binding (hnRNP) K protein and the fragile X mental retardation gene product (FMR1) [10].
 

Chemical compound and disease context of Conserved Sequence

 

Biological context of Conserved Sequence

 

Anatomical context of Conserved Sequence

 

Associations of Conserved Sequence with chemical compounds

 

Gene context of Conserved Sequence

 

Analytical, diagnostic and therapeutic context of Conserved Sequence

References

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