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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Conserved Sequence

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Disease relevance of Conserved Sequence


High impact information on Conserved Sequence

  • Finally, components of both the APC and the SCF E3 ubiquitin-ligase complex contain several conserved sequence motifs, including WD-40 repeats and cullin homology domains, which suggest that both complexes may use a similar mechanism for substrate ubiquitination [6].
  • MLH3 is more similar to mismatch repair proteins from yeast, plants, worms and bacteria than to any known mammalian protein, suggesting that its conserved sequence may confer unique functions in mice and humans [7].
  • One face of the complex exposes the sequence-conserved phosphate-binding region on Cks and the ATP-binding site on CDK2, suggesting that CKs may target CDK2 to other phosphoproteins during the cell cycle [8].
  • Ugi binds the sequence-conserved DNA-binding groove of UDG via shape and electrostatic complementarity, specific charged hydrogen bonds, and hydrophobic packing enveloping Leu-272 from a protruding UDG loop [9].
  • The KH domain is an evolutionarily conserved sequence motif present in many RNA-binding proteins, including the pre-mRNA-binding (hnRNP) K protein and the fragile X mental retardation gene product (FMR1) [10].

Chemical compound and disease context of Conserved Sequence


Biological context of Conserved Sequence


Anatomical context of Conserved Sequence


Associations of Conserved Sequence with chemical compounds


Gene context of Conserved Sequence


Analytical, diagnostic and therapeutic context of Conserved Sequence


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  2. A conserved sequence at c-myc oncogene chromosomal translocation breakpoints in plasmacytomas. Piccoli, S.P., Caimi, P.G., Cole, M.D. Nature (1984) [Pubmed]
  3. Escherichia coli formylmethionine tRNA: mutations in GGGCCC sequence conserved in anticodon stem of initiator tRNAs affect initiation of protein synthesis and conformation of anticodon loop. Seong, B.L., RajBhandary, U.L. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
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  8. Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1. Bourne, Y., Watson, M.H., Hickey, M.J., Holmes, W., Rocque, W., Reed, S.I., Tainer, J.A. Cell (1996) [Pubmed]
  9. Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA. Mol, C.D., Arvai, A.S., Sanderson, R.J., Slupphaug, G., Kavli, B., Krokan, H.E., Mosbaugh, D.W., Tainer, J.A. Cell (1995) [Pubmed]
  10. Essential role for KH domains in RNA binding: impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome. Siomi, H., Choi, M., Siomi, M.C., Nussbaum, R.L., Dreyfuss, G. Cell (1994) [Pubmed]
  11. Mutants of Escherichia coli formylmethionine tRNA: a single base change enables initiator tRNA to act as an elongator in vitro. Seong, B.L., RajBhandary, U.L. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  12. Identification of an assembly domain in the small subunit of ribulose-1,5-bisphosphate carboxylase. Wasmann, C.C., Ramage, R.T., Bohnert, H.J., Ostrem, J.A. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  13. Structural insights into the mechanism of nuclease A, a betabeta alpha metal nuclease from Anabaena. Ghosh, M., Meiss, G., Pingoud, A., London, R.E., Pedersen, L.C. J. Biol. Chem. (2005) [Pubmed]
  14. Thr-431 and Arg-433 are part of a conserved sequence motif of the glutamine amidotransferase domain of CTP synthases and are involved in GTP activation of the Lactococcus lactis enzyme. Willemoës, M. J. Biol. Chem. (2003) [Pubmed]
  15. Role of conserved Asn-Tyr-Asp-Tyr sequence in bacterial copper/2,4, 5-trihydroxyphenylalanyl quinone-containing histamine oxidase. Choi, Y.H., Matsuzaki, R., Suzuki, S., Tanizawa, K. J. Biol. Chem. (1996) [Pubmed]
  16. Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis. Mol, C.D., Arvai, A.S., Slupphaug, G., Kavli, B., Alseth, I., Krokan, H.E., Tainer, J.A. Cell (1995) [Pubmed]
  17. Evidence for the biochemical role of an internal sequence in yeast nuclear mRNA introns: implications for U1 RNA and metazoan mRNA splicing. Pikielny, C.W., Teem, J.L., Rosbash, M. Cell (1983) [Pubmed]
  18. Interlocked RNA circle formation by a self-splicing yeast mitochondrial group I intron. Tabak, H.F., Van der Horst, G., Kamps, A.M., Arnberg, A.C. Cell (1987) [Pubmed]
  19. A conserved sequence in the immunoglobulin J kappa-C kappa intron: possible enhancer element. Emorine, L., Kuehl, M., Weir, L., Leder, P., Max, E.E. Nature (1983) [Pubmed]
  20. STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor. Pfeffer, L.M., Mullersman, J.E., Pfeffer, S.R., Murti, A., Shi, W., Yang, C.H. Science (1997) [Pubmed]
  21. Evolutionarily conserved sequence elements that positively regulate IFN-gamma expression in T cells. Shnyreva, M., Weaver, W.M., Blanchette, M., Taylor, S.L., Tompa, M., Fitzpatrick, D.R., Wilson, C.B. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  22. Chromosome walking on the TCL1 locus involved in T-cell neoplasia. Virgilio, L., Isobe, M., Narducci, M.G., Carotenuto, P., Camerini, B., Kurosawa, N., Abbas-ar-Rushdi, n.u.l.l., Croce, C.M., Russo, G. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  23. Evidence that facilitative glucose transporters may fold as beta-barrels. Fischbarg, J., Cheung, M., Czegledy, F., Li, J., Iserovich, P., Kuang, K., Hubbard, J., Garner, M., Rosen, O.M., Golde, D.W. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  24. Cytoplasmic protein binding to highly conserved sequences in the 3' untranslated region of mouse protamine 2 mRNA, a translationally regulated transcript of male germ cells. Kwon, Y.K., Hecht, N.B. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  25. Substrate-induced transmembrane signaling in the cobalamin transporter BtuB. Chimento, D.P., Mohanty, A.K., Kadner, R.J., Wiener, M.C. Nat. Struct. Biol. (2003) [Pubmed]
  26. Organization of minicircle genes for guide RNAs in Trypanosoma brucei. Pollard, V.W., Rohrer, S.P., Michelotti, E.F., Hancock, K., Hajduk, S.L. Cell (1990) [Pubmed]
  27. Amino-acid sequence of the catalytic subunit of the (Na+ + K+)ATPase deduced from a complementary DNA. Shull, G.E., Schwartz, A., Lingrel, J.B. Nature (1985) [Pubmed]
  28. A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family. Strauss, E.J., Guthrie, C. Genes Dev. (1991) [Pubmed]
  29. Progressively restricted expression of a homeo box gene within the aboral ectoderm of developing sea urchin embryos. Angerer, L.M., Dolecki, G.J., Gagnon, M.L., Lum, R., Wang, G., Yang, Q., Humphreys, T., Angerer, R.C. Genes Dev. (1989) [Pubmed]
  30. Two phases in the addition of a poly(A) tail. Sheets, M.D., Wickens, M. Genes Dev. (1989) [Pubmed]
  31. Epidermal growth factor receptor occupancy inhibits vaccinia virus infection. Eppstein, D.A., Marsh, Y.V., Schreiber, A.B., Newman, S.R., Todaro, G.J., Nestor, J.J. Nature (1985) [Pubmed]
  32. Insights into DNA recombination from the structure of a RAD51-BRCA2 complex. Pellegrini, L., Yu, D.S., Lo, T., Anand, S., Lee, M., Blundell, T.L., Venkitaraman, A.R. Nature (2002) [Pubmed]
  33. Complementation of the DNA repair defect in xeroderma pigmentosum group G cells by a human cDNA related to yeast RAD2. Scherly, D., Nouspikel, T., Corlet, J., Ucla, C., Bairoch, A., Clarkson, S.G. Nature (1993) [Pubmed]
  34. A permease-oxidase complex involved in high-affinity iron uptake in yeast. Stearman, R., Yuan, D.S., Yamaguchi-Iwai, Y., Klausner, R.D., Dancis, A. Science (1996) [Pubmed]
  35. The mec-3 gene contains cis-acting elements mediating positive and negative regulation in cells produced by asymmetric cell division in Caenorhabditis elegans. Way, J.C., Wang, L., Run, J.Q., Wang, A. Genes Dev. (1991) [Pubmed]
  36. Comparative analysis of ribonuclease P RNA using gene sequences from natural microbial populations reveals tertiary structural elements. Brown, J.W., Nolan, J.M., Haas, E.S., Rubio, M.A., Major, F., Pace, N.R. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  37. The hinge and chromo shadow domain impart distinct targeting of HP1-like proteins. Smothers, J.F., Henikoff, S. Mol. Cell. Biol. (2001) [Pubmed]
  38. Direct evidence for the expression of multiple endogenous retroviruses in the synovial compartment in rheumatoid arthritis. Nakagawa, K., Brusic, V., McColl, G., Harrison, L.C. Arthritis Rheum. (1997) [Pubmed]
  39. Site-specific mutagenesis on a human initiator methionine tRNA gene within a sequence conserved in all eukaryotic initiator tRNAs and studies of its effects on in vitro transcription. Drabkin, H.J., RajBhandary, U.L. J. Biol. Chem. (1985) [Pubmed]
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