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Gene Review

PKD2L2  -  polycystic kidney disease 2-like 2

Homo sapiens

Synonyms: Polycystic kidney disease 2-like 2 protein, Polycystin-2L2, Polycystin-L2, TRPP5
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High impact information on PKD2L2

  • PKD2L2 consists of 17 exons spanning approximately 50 kb of genomic DNA [1].
  • Full-length cDNA sequences for both mouse and human polycystin-L2 were obtained from testis cDNA [1].
  • PKD2L2 and PKD2L, which encode proteins of 613 and 805 amino acids, are approximately 65% similar to polycystin-2 [2].

Analytical, diagnostic and therapeutic context of PKD2L2

  • Sequence analysis predicts that the mouse and human polycystin-L2 proteins consist of 621 and 624 amino acid residues, respectively [1].


  1. Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization. Guo, L., Schreiber, T.H., Weremowicz, S., Morton, C.C., Lee, C., Zhou, J. Genomics (2000) [Pubmed]
  2. Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2). Veldhuisen, B., Spruit, L., Dauwerse, H.G., Breuning, M.H., Peters, D.J. Eur. J. Hum. Genet. (1999) [Pubmed]
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