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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

tnpA  -  hypothetical protein

Escherichia coli

 
 
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High impact information on tnpA

  • Five single base pair mutations that increase expression of the tnpA (transposase) gene of the Tn3 transposon approximately 30-fold, but which still allow the gene to be regulated, have been isolated by using a generally applicable procedure that involves distally linked lac gene fusions [1].
  • In order to determine the extent of the res site we have constructed in vitro a series of deletions that terminate within the tnpA-tnpR intergenic region, and have analyzed their effect on site-specific recombination [2].
  • Our results indicate that a fully functional res site is about 115 base-pairs (bp) and runs from a position 15 bp to the left (tnpA-proximal) side of the crossover point to 100 bp to the right [2].

References

  1. Overproduction of the Tn3 transposition protein and its role in DNA transposition. Casadaban, M.J., Chou, J., Cohen, S.N. Cell (1982) [Pubmed]
  2. Analysis of the gamma delta res site. Sites required for site-specific recombination and gene expression. Wells, R.G., Grindley, N.D. J. Mol. Biol. (1984) [Pubmed]
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