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Gene Review:

psiB - plasmid SOS inhibition protein B

Escherichia coli

Dutreix, M. et al., Jones, A.L. et al., Bagdasarian, M. et al.

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High impact information on psiB

Loss of the Psi function, resulting from the insertion of Tn3 into psi+, greatly reduced the synthesis of two proteins, designated PsiA (Mr 24,500) and PsiB (Mr 12,500) [1].
The Incl1 conjugative plasmid Collb-P9 carries a psiB gene that prevents induction of the SOS response in host bacteria [2].
PsiB protein of plasmid R6-5 inhibits the induction of the SOS pathway [3].
Hence, the F sex factor may be unable to prevent SOS induction for two non-exclusive reasons: (i) F PsiB protein, being slightly different from R6-5, may be less active, (ii) the level of synthesis of F PsiB protein may be insufficient to prevent SOS induction [3].

Biological context of psiB

Carriage of the psiB gene by Collb is shown to prevent a low level of SOS induction following conjugation [2].

References

An inhibitor of SOS induction, specified by a plasmid locus in Escherichia coli. Bagdasarian, M., Bailone, A., Bagdasarian, M.M., Manning, P.A., Lurz, R., Timmis, K.N., Devoret, R. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
Zygotic induction of plasmid ssb and psiB genes following conjugative transfer of Incl1 plasmid Collb-P9. Jones, A.L., Barth, P.T., Wilkins, B.M. Mol. Microbiol. (1992) [Pubmed]
Identification of psiB genes of plasmids F and R6-5. Molecular basis for psiB enhanced expression in plasmid R6-5. Dutreix, M., Bäckman, A., Célérier, J., Bagdasarian, M.M., Sommer, S., Bailone, A., Devoret, R., Bagdasarian, M. Nucleic Acids Res. (1988) [Pubmed]

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