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Gene Review:

TTC1546 - homoaconitate hydratase small subunit

Thermus thermophilus HB27

Nishida, H. et al., Kobashi, N. et al., Kosuge, T. et al.

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Disease relevance of TTC1546

In previous studies we determined the nucleotide sequence of the gene cluster containing lys20, hacA (lys4A), hacB (lys4B), orfE, orfF, rimK, argC, and argB of Thermus thermophilus, an extremely thermophilic bacterium [1].

High impact information on TTC1546

Determination of the nucleotide sequence suggested the presence of homoaconitate hydratase genes, termed hacA and hacB, which could encode large and small subunits of homoaconitate hydratase, in the cloned fragment [2].
LYS20 and LYS4, which respectively encode homocitrate synthase and homoaconitate hydratase have already been identified as the lysine biosynthetic genes in T. thermophilus HB27 [3].

References

A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway: a key to the evolution of amino acid biosynthesis. Nishida, H., Nishiyama, M., Kobashi, N., Kosuge, T., Hoshino, T., Yamane, H. Genome Res. (1999) [Pubmed]
Aspartate kinase-independent lysine synthesis in an extremely thermophilic bacterium, Thermus thermophilus: lysine is synthesized via alpha-aminoadipic acid not via diaminopimelic acid. Kobashi, N., Nishiyama, M., Tanokura, M. J. Bacteriol. (1999) [Pubmed]
The alpha-aminoadipate pathway for lysine biosynthesis is widely distributed among Thermus strains. Kosuge, T., Hoshino, T. J. Biosci. Bioeng. (1999) [Pubmed]

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