Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

UBB - ubiquitin B

Bos taurus

Flierman, D. et al., Badciong, J.C. et al., Wempe, F. et al.

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High impact information on LOC281370

We have tested whether the release of a polypeptide chain into the cytosol is caused by a ratcheting mechanism in which the attachment of polyubiquitin prevents the chain from moving back into the endoplasmic reticulum [1].
This study also suggests that ubiquitination of Mdm2 and MdmX may not serve as a signal for degradation, as we show that each are capable of synthesizing non-lysine 48 polyubiquitin chains and, in fact, utilize multiple lysine linkages [2].
Sequence analysis of pUF4AA revealed a coding region for a polyubiquitin with four tandem-repeats [3].

Anatomical context of LOC281370

Polyubiquitin serves as a recognition signal, rather than a ratcheting molecule, during retrotranslocation of proteins across the endoplasmic reticulum membrane [1].

References

Polyubiquitin serves as a recognition signal, rather than a ratcheting molecule, during retrotranslocation of proteins across the endoplasmic reticulum membrane. Flierman, D., Ye, Y., Dai, M., Chau, V., Rapoport, T.A. J. Biol. Chem. (2003) [Pubmed]
MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination. Badciong, J.C., Haas, A.L. J. Biol. Chem. (2002) [Pubmed]
Characterization of a full-length cDNA encoding a bovine four tandem-repeat ubiquitin. Wempe, F., Scheit, K.H. Biochim. Biophys. Acta (1993) [Pubmed]

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AgaP_AGAP002599	Anopheles gambiae str. PEST
UBQ3	Arabidopsis thaliana
UBQ14	Arabidopsis thaliana
CG11700	Drosophila melanogaster
LOC101747587	Gallus gallus
Ubb	Mus musculus
Ubb	Rattus norvegicus
ubc	Xenopus (Silurana) tropicalis

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