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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TSFM  -  Ts translation elongation factor,...

Bos taurus

 
 
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Disease relevance of TSFM

 

High impact information on TSFM

  • Surprisingly, EF-Ts monomers created in this manner failed to catalyze nucleotide exchange in EF-Tu, indicating that, in vitro [2].
  • Here we report the crystal structure of the dimerization domain of EF-Ts from T. thermophilus refined to 1.7 A resolution [2].
  • Characterization of the interaction between the nucleotide exchange factor EF-Ts from nematode mitochondria and elongation factor Tu [3].
 

Physical interactions of TSFM

  • Thermus thermophilus EF-Ts exists as a stable dimer in solution which binds two molecules of EF-Tu to form a (EF-Tu.EF-Ts)2 heterotetramer [2].
 

Regulatory relationships of TSFM

  • In contrast to earlier experiments, purification of free mitochondrial EF-Ts was accomplished under nondenaturing conditions since only about 60% of the expressed EF-Ts copurified with E. coli EF-Tu [4].

References

  1. Crystal structure of the bovine mitochondrial elongation factor Tu.Ts complex. Jeppesen, M.G., Navratil, T., Spremulli, L.L., Nyborg, J. J. Biol. Chem. (2005) [Pubmed]
  2. Structure and importance of the dimerization domain in elongation factor Ts from Thermus thermophilus. Jiang, Y., Nock, S., Nesper, M., Sprinzl, M., Sigler, P.B. Biochemistry (1996) [Pubmed]
  3. Characterization of the interaction between the nucleotide exchange factor EF-Ts from nematode mitochondria and elongation factor Tu. Ohtsuki, T., Sakurai, M., Sato, A., Watanabe, K. Nucleic Acids Res. (2002) [Pubmed]
  4. Isolation, crystallisation, and preliminary X-ray analysis of the bovine mitochondrial EF-Tu:GDP and EF-Tu:EF-Ts complexes. Karring, H., Andersen, G.R., Thirup, S.S., Nyborg, J., Spremulli, L.L., Clark, B.F. Biochim. Biophys. Acta (2002) [Pubmed]
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