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Gene Review:

CNGB1 - cyclic nucleotide gated channel beta 1

Bos taurus

Molokanova, E. et al., Trudeau, M.C. et al.

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High impact information on CNGB1

Thus, disruption of a regulatory interaction by mutation in CNGA1 exposed a region of CNGB1 that disrupted surface expression of heteromeric CNGA1-RP/CNGB1 channels, accounting for this instance of RP [1].
Hence both CNGA1 and CNGB1 subunits contribute to phosphorylation-dependent modulation of rod CNG channels, but the phosphorylation states of the two subunits are regulated in different ways [2].
Unlike CNGA1, CNGB1 does not exhibit activity dependence of modulation by tyrosine phosphorylation [2].
Replacement of either Y498 of CNGA1 or Y1097 of CNGB1 with phenylalanine reduces modulation, and removal of both tyrosines eliminates modulation [2].

Biological context of CNGB1

Here we show that the CNGB1 subunit contains a specific tyrosine (Y1097) that is important for modulation of heteromeric channels by tyrosine phosphorylation [2].

References

An intersubunit interaction regulates trafficking of rod cyclic nucleotide-gated channels and is disrupted in an inherited form of blindness. Trudeau, M.C., Zagotta, W.N. Neuron (2002) [Pubmed]
Subunit contributions to phosphorylation-dependent modulation of bovine rod cyclic nucleotide-gated channels. Molokanova, E., Krajewski, J.L., Satpaev, D., Luetje, C.W., Kramer, R.H. J. Physiol. (Lond.) (2003) [Pubmed]

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tax-2	Caenorhabditis elegans
CNGB1	Canis lupus familiaris
CNGB1	Gallus gallus
CNGB1	Homo sapiens
CNGB1	Macaca mulatta
CNGB1	Pan troglodytes
Cngb1	Rattus norvegicus

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