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Gene Review

micA  -  ncRNA

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2682, JWR0246, psrA10, sraD
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High impact information on micA

  • Belongs to the σ E regulon [1]
  • Guide sRNA for Hfq-dependent ompA mRNA decay [2][3]
  • Deletion of sraD, however, does not significantly affect the stability of the ompA mRNA in slowly growing cells [3].
  • Binds the divergently transcribed luxS (prev. ygaG) mRNA and this complex is processed by the dsRNA-specific ribonuclease, RNase III . [Udekwu, Klas Ifeanyi (2007). Functional characterization of the small antisense RNA MicA in Escherichia coli.   (2009-01-02)]


  1. Sigma E controls biogenesis of the antisense RNA MicA. Udekwu, K.I., Wagner, E.G. Nucleic. Acids. Res. (2007) [Pubmed]
  2. Hfq-dependent regulation of OmpA synthesis is mediated by an antisense RNA. Udekwu, K.I., Darfeuille, F., Vogel, J., Reimegård, J., Holmqvist, E., Wagner, E.G. Genes. Dev. (2005) [Pubmed]
  3. Regulation of ompA mRNA stability: the role of a small regulatory RNA in growth phase-dependent control. Rasmussen, A.A., Eriksen, M., Gilany, K., Udesen, C., Franch, T., Petersen, C., Valentin-Hansen, P. Mol. Microbiol. (2005) [Pubmed]
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