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Gene Review

TRDC  -  T cell receptor delta constant

Homo sapiens

Synonyms: T-cell receptor delta chain C region
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High impact information on TRDC

  • Screening of 37 other T-ALLs revealed one additional case with expression of the BCL11B-TRDC fusion transcript [1].
  • The minke whale Cdelta sequences were all identical, and showed 86% nucleotide and 77.8% amino acid sequence similarity to the human TRDC gene [2].


  1. Disruption of the BCL11B gene through inv(14)(q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transcripts in T-ALL. Przybylski, G.K., Dik, W.A., Wanzeck, J., Grabarczyk, P., Majunke, S., Martin-Subero, J.I., Siebert, R., Dölken, G., Ludwig, W.D., Verhaaf, B., van Dongen, J.J., Schmidt, C.A., Langerak, A.W. Leukemia (2005) [Pubmed]
  2. Isolation of T cell receptor gamma/delta chain constant genes from minke whale. Zhang, X.M., Huck, S., Dariavach, P., Spilliaert, R., Arnason, A., Soua, Z., Lefranc, G., Lefranc, M.P. Exp. Clin. Immunogenet. (1995) [Pubmed]
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