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Gene Review

BCL11B  -  B-cell CLL/lymphoma 11B (zinc finger protein)

Homo sapiens

Synonyms: ATL1, ATL1-alpha, ATL1-beta, ATL1-delta, ATL1-gamma, ...
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Disease relevance of BCL11B


High impact information on BCL11B


Biological context of BCL11B


Anatomical context of BCL11B


Associations of BCL11B with chemical compounds


Regulatory relationships of BCL11B

  • We report that CTIP2 represses Sp1- and COUP-TF-mediated activation of HIV-1 gene transcription and viral replication as a result of physical interactions with COUP-TF and Sp1 in microglial nuclei [9].

Other interactions of BCL11B

  • Here, we demonstrate the association of the endogenous BCL11B with the nucleosome remodeling and histone deacetylase (NuRD) complex, one of the major transcriptional corepressor complexes in mammalian cells [6].
  • Screening of 37 other T-ALLs revealed one additional case with expression of the BCL11B-TRDC fusion transcript [10].
  • The TRDV1-BCL11B joining region was 1344 bp long and contained fragments derived from 20q11.22, 3p21.33 and from 11p12, indicating the complex character of this aberration [10].
  • Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2 (CTIP2), also known as Bcl11b, is a transcriptional repressor that functions by direct, sequence-specific DNA binding activity or by recruitment to the promoter template by interaction with COUP-TF family members [8].
  • We report a novel chromosomal translocation in a T-ALL patient that maps upstream of the HOXA13 gene and downstream of the BCL11B/CTIP2 locus [11].

Analytical, diagnostic and therapeutic context of BCL11B

  • Using laser confocal microscopy CTIP2 was found to colocalize with Sp1, COUP-TF and the heterochromatin-associated protein Hp1alpha, which is mainly detected in transcriptionally repressed heterochromatic region [9].


  1. A novel t(6;14)(q25-q27;q32) in acute myelocytic leukemia involves the BCL11B gene. Bezrookove, V., van Zelderen-Bhola, S.L., Brink, A., Szuhai, K., Raap, A.K., Barge, R., Beverstock, G.C., Rosenberg, C. Cancer Genet. Cytogenet. (2004) [Pubmed]
  2. The cardiac homeobox gene NKX2-5 is deregulated by juxtaposition with BCL11B in pediatric T-ALL cell lines via a novel t(5;14)(q35.1;q32.2). Nagel, S., Kaufmann, M., Drexler, H.G., MacLeod, R.A. Cancer Res. (2003) [Pubmed]
  3. BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes. Cismasiu, V.B., Ghanta, S., Duque, J., Albu, D.I., Chen, H.M., Kasturi, R., Avram, D. Blood (2006) [Pubmed]
  4. HOX11L2/TLX3 is transcriptionally activated through T-cell regulatory elements downstream of BCL11B as a result of the t(5;14)(q35;q32). Su, X.Y., Della-Valle, V., Andre-Schmutz, I., Lemercier, C., Radford-Weiss, I., Ballerini, P., Lessard, M., Lafage-Pochitaloff, M., Mugneret, F., Berger, R., Romana, S.P., Bernard, O.A., Penard-Lacronique, V. Blood (2006) [Pubmed]
  5. The BCL11 gene family: involvement of BCL11A in lymphoid malignancies. Satterwhite, E., Sonoki, T., Willis, T.G., Harder, L., Nowak, R., Arriola, E.L., Liu, H., Price, H.P., Gesk, S., Steinemann, D., Schlegelberger, B., Oscier, D.G., Siebert, R., Tucker, P.W., Dyer, M.J. Blood (2001) [Pubmed]
  6. BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter. Cismasiu, V.B., Adamo, K., Gecewicz, J., Duque, J., Lin, Q., Avram, D. Oncogene (2005) [Pubmed]
  7. COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein. Avram, D., Fields, A., Senawong, T., Topark-Ngarm, A., Leid, M. Biochem. J. (2002) [Pubmed]
  8. CTIP2 Associates with the NuRD Complex on the Promoter of p57KIP2, a Newly Identified CTIP2 Target Gene. Topark-Ngarm, A., Golonzhka, O., Peterson, V.J., Barrett, B., Martinez, B., Crofoot, K., Filtz, T.M., Leid, M. J. Biol. Chem. (2006) [Pubmed]
  9. COUP-TF interacting protein 2 represses the initial phase of HIV-1 gene transcription in human microglial cells. Marban, C., Redel, L., Suzanne, S., Van Lint, C., Lecestre, D., Chasserot-Golaz, S., Leid, M., Aunis, D., Schaeffer, E., Rohr, O. Nucleic Acids Res. (2005) [Pubmed]
  10. Disruption of the BCL11B gene through inv(14)(q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transcripts in T-ALL. Przybylski, G.K., Dik, W.A., Wanzeck, J., Grabarczyk, P., Majunke, S., Martin-Subero, J.I., Siebert, R., Dölken, G., Ludwig, W.D., Verhaaf, B., van Dongen, J.J., Schmidt, C.A., Langerak, A.W. Leukemia (2005) [Pubmed]
  11. Transforming potential of the T-cell acute lymphoblastic leukemia-associated homeobox genes HOXA13, TLX1, and TLX3. Su, X., Drabkin, H., Clappier, E., Morgado, E., Busson, M., Romana, S., Soulier, J., Berger, R., Bernard, O.A., Lavau, C. Genes Chromosomes Cancer (2006) [Pubmed]
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