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Gene Review:

TRBV5-1 - T cell receptor beta variable 5-1

Homo sapiens

Synonyms: TCRBV5S1, TCRBV5S1A1T, TRBV51

Hawes, G.E. et al., Frauendorf, E. et al.

Frauendorf, von Goessel, May, Märker-Hermann,

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Disease relevance of TRBV5-1

However, a striking observation was made: even though high responders have a diverse specific TcR repertoire, TRBV5-expressing clones from two healthy individuals could be isolated that were nearly identical to a dominant clone in the tuberculoid leprosy patient [1].

High impact information on TRBV5-1

LRRYLENGK-specific T cell clones used preferentially the TCRBV5S1 and the BV14 segment [2].
Previously we have shown that the T-cell response against the HLA-DR3 (17)-restricted heat shock protein (Mr 65 000)-derived peptide amino acids (aa) 3-13 (hsp65 aa 3-13) is recognized by the exclusive usage of the TRBV5 gene as well as a conserved CDR3 region in a tuberculoid leprosy patient [1].

References

Conserved TcR beta chain usage for a single MHC class II-restricted heat shock protein peptide. Hawes, G.E., Struyk, L., Beacock-Sharp, H., Henwood, J., Hill Gaston, J.S., van den Elsen, P.J. Immunogenetics (1998) [Pubmed]
HLA-B27-restricted T cells from patients with ankylosing spondylitis recognize peptides from B*2705 that are similar to bacteria-derived peptides. Frauendorf, E., von Goessel, H., May, E., Märker-Hermann, E. Clin. Exp. Immunol. (2003) [Pubmed]

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