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MeSH Review

Leprosy, Tuberculoid

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Disease relevance of Leprosy, Tuberculoid

  • Similarly, the absence of TGF-beta 1 in tuberculoid leprosy, which progresses with a specific immune response to M. leprae, may explain the intense differentiation of macrophage cells with the formation of well defined epithelioid granulomas capable of eliminating most of the bacilli [1].
  • The patient had multiple peripheral nerve palsies as a result of tuberculoid leprosy and had been resident in the leprosy ward of Goroka Base Hospital for over 6 years [2].
  • Neither sera from healthy controls nor sera from patients with pulmonary tuberculosis recognized the 35-kDa protein, and only one of four serum samples from patients with borderline tuberculoid leprosy reacted with this protein [3].
  • Sera from patients with lepromatous and tuberculoid leprosy were examined in immunoblot assays for antibodies to Mycobacterium tuberculosis culture filtrate antigens [4].
  • The serum 125I-C1q binding activity was found to be increased by more than 2 s.d., as compared to the normal values, in most of the sera from patients with erythema nodosum leprosum (ENL) (80%) and uncomplicated lepromatous leprosy (82%), but also in the sera from patients with tuberculoid leprosy (58%) [5].

High impact information on Leprosy, Tuberculoid


Chemical compound and disease context of Leprosy, Tuberculoid


Anatomical context of Leprosy, Tuberculoid


Gene context of Leprosy, Tuberculoid


Analytical, diagnostic and therapeutic context of Leprosy, Tuberculoid


  1. Detection of transforming growth factor-beta 1 in dermal lesions of different clinical forms of leprosy. Goulart, I.M., Figueiredo, F., Coimbra, T., Foss, N.T. Am. J. Pathol. (1996) [Pubmed]
  2. Huntington's disease and leprosy in a New Guinea Highlander. Scrimgeour, E.M. J. Med. Genet. (1983) [Pubmed]
  3. Identification of an immunostimulating protein from Mycobacterium leprae. Mohagheghpour, N., Munn, M.W., Gelber, R.H., Engleman, E.G. Infect. Immun. (1990) [Pubmed]
  4. Serological responses of patients with lepromatous and tuberculoid leprosy to 30-, 31-, and 32-kilodalton antigens of Mycobacterium tuberculosis. Rumschlag, H.S., Shinnick, T.M., Cohen, M.L. J. Clin. Microbiol. (1988) [Pubmed]
  5. Immune complexes and complement hypercatabolism in patients with leprosy. Bjorvatn, B., Barnetson, R.S., Kronvall, G., Zubler, R.H., Lambert, P.H. Clin. Exp. Immunol. (1976) [Pubmed]
  6. Arginine at positions 13 or 70-71 in pocket 4 of HLA-DRB1 alleles is associated with susceptibility to tuberculoid leprosy. Zerva, L., Cizman, B., Mehra, N.K., Alahari, S.K., Murali, R., Zmijewski, C.M., Kamoun, M., Monos, D.S. J. Exp. Med. (1996) [Pubmed]
  7. Immunohistologic assessment of cytokine production of infiltrating cells in various forms of leprosy. Arnoldi, J., Gerdes, J., Flad, H.D. Am. J. Pathol. (1990) [Pubmed]
  8. Association of vitamin D receptor genotype with leprosy type. Roy, S., Frodsham, A., Saha, B., Hazra, S.K., Mascie-Taylor, C.G., Hill, A.V. J. Infect. Dis. (1999) [Pubmed]
  9. Identification and characterization of antigenic determinants of Mycobacterium leprae that react with antibodies in sera of leprosy patients. Sathish, M., Esser, R.E., Thole, J.E., Clark-Curtiss, J.E. Infect. Immun. (1990) [Pubmed]
  10. Interleukin 1 production by peripheral blood mononuclear cells from leprosy patients. Watson, S., Bullock, W., Nelson, K., Schauf, V., Gelber, R., Jacobson, R. Infect. Immun. (1984) [Pubmed]
  11. Sparing of tuberculoid leprosy patch in a patient with dapsone hypersensitivity syndrome. Ng, P.P., Goh, C.L. J. Am. Acad. Dermatol. (1998) [Pubmed]
  12. Hormonal changes associated with testicular atrophy and gynaecomastia in patients with leprosy. Morley, J.E., Distiller, L.A., Sagel, J., Kok, S.H., Kay, G., Carr, P., Katz, M. Clin. Endocrinol. (Oxf) (1977) [Pubmed]
  13. Co-stimulatory signals increase the reactivity of gammadelta T cells towards mycobacterial antigens. González-Amaro, R., Portales-Pérez, D.P., Baranda, L., Moncada, B., Toro, C., López-Briones, S., Espitia, C., Mancilla, R. Clin. Exp. Immunol. (2000) [Pubmed]
  14. Prostaglandin-dependent regulation of the in vitro proliferative response to mycobacterial antigens of peripheral blood lymphocytes from normal donors and from patients with tuberculosis or leprosy. Bahr, G.M., Rook, G.A., Stanford, J.L. Clin. Exp. Immunol. (1981) [Pubmed]
  15. Tumor necrosis factor-alpha promoter polymorphism TNF2 is associated with a stronger delayed-type hypersensitivity reaction in the skin of borderline tuberculoid leprosy patients. Moraes, M.O., Duppre, N.C., Suffys, P.N., Santos, A.R., Almeida, A.S., Nery, J.A., Sampaio, E.P., Sarno, E.N. Immunogenetics (2001) [Pubmed]
  16. Monocyte derived IL 10 and PGE2 are associated with the absence of Th 1 cells and in vitro T cell suppression in lepromatous leprosy. Misra, N., Selvakumar, M., Singh, S., Bharadwaj, M., Ramesh, V., Misra, R.S., Nath, I. Immunol. Lett. (1995) [Pubmed]
  17. High expression of myeloid-related proteins 8 and 14 characterizes an inflammatorily active but ineffective response of macrophages during leprosy. Sunderkötter, C.H., Tomimori-Yamashita, J., Nix, V., Maeda, S.M., Sindrilaru, A., Mariano, M., Sorg, C., Roth, J. Immunology (2004) [Pubmed]
  18. Mycobacterium leprae DNA content, cellular and cytokine patterns in skin lesions of leprosy patients undergoing multidrug therapy (MDT). Flad, H.D., Richter, E., Schlüter, C., Duchrow, M., Arnoldi, J., Hahn, M., Graf von Ballestrem, W., Alvarenga, A.E., Gerdes, J. Immunobiology (1994) [Pubmed]
  19. Quantitation of the soluble E-receptor of human T lymphocytes by rocket electrophoresis in the serum of patients with lepromatous and tuberculoid leprosy. Longo, I.M., Moura, N.C., Opromolla, D., Mendes, N.F. Medicina (B Aires) (1991) [Pubmed]
  20. Dapsone dependent nodular panniculitis. Uplekar, M.W., Antia, N.H. Indian journal of leprosy. (1986) [Pubmed]
  21. Cytokine profile of circulating T cells of leprosy patients reflects both indiscriminate and polarized T-helper subsets: T-helper phenotype is stable and uninfluenced by related antigens of Mycobacterium leprae. Misra, N., Murtaza, A., Walker, B., Narayan, N.P., Misra, R.S., Ramesh, V., Singh, S., Colston, M.J., Nath, I. Immunology (1995) [Pubmed]
  22. Analysis of the immunogenetic background of Japanese leprosy patients by the HLA system. Izumi, S., Sugiyama, K., Matsumoto, Y., Ohkawa, S. Vox Sang. (1982) [Pubmed]
  23. Immunohistochemistry in histoid leprosy. Kontochristopoulos, G.J., Aroni, K., Panteleos, D.N., Tosca, A.D. International journal of dermatology. (1995) [Pubmed]
  24. Expression of cyclooxygenase type 2 in lepromatous and tuberculoid leprosy lesions. Kiszewski, A.E., Becerril, E., Baquera, J., Ruiz-Maldonado, R., Hernández Pando, R. Br. J. Dermatol. (2003) [Pubmed]
  25. Clonal dominance and selection for similar complementarity determining region 3 motifs among T lymphocytes responding to the HLA-DR3-associated Mycobacterium leprae heat shock protein 65-kd peptide 3-13. Struyk, L., Hawes, G.E., Haanen, J.B., de Vries, R.R., van den Elsen, P.J. Hum. Immunol. (1995) [Pubmed]
  26. Renal transplantation in leprosy. Date, A., Mathai, R., Pandey, A.P., Shastry, J.C. Int. J. Lepr. Other Mycobact. Dis. (1982) [Pubmed]
  27. Comparative study of CD26 as a Th1-like and CD30 as a potential Th2-like operational marker in leprosy. Seitzer, U., Scheel-Toellner, D., Hahn, M., Heinemann, G., Mattern, T., Flad, H.D., Gerdes, J. Adv. Exp. Med. Biol. (1997) [Pubmed]
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