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Gene Review

diexf  -  digestive organ expansion factor homolog

Danio rerio

Synonyms: Digestive organ expansion factor, SO:0000704, chunp6870, def, dj434o14.5, ...
 
 
 
 
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High impact information on def

  • A loss-of-function mutation in def confers hypoplastic digestive organs and selectively up-regulates the expression of Delta113p53, counterpart to a newly identified isoform of p53 produced by an alternative internal promoter in intron 4 of the p53 gene in human [1].

References

  1. Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish. Chen, J., Ruan, H., Ng, S.M., Gao, C., Soo, H.M., Wu, W., Zhang, Z., Wen, Z., Lane, D.P., Peng, J. Genes Dev. (2005) [Pubmed]
 
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