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Gene Review

NDUFS8  -  NADH dehydrogenase (ubiquinone) Fe-S...

Bos taurus

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Disease relevance of NDUFS8

  • The NuoI subunit of the Rhodobacter capsulatus respiratory Complex I (equivalent to the bovine TYKY subunit) is required for proper assembly of the membraneous and peripheral domains of the enzyme [1].

High impact information on NDUFS8

  • It was recently shown that the TYKY subunit is not an ordinary 2[4Fe-4S] ferredoxin, but has a unique amino acid sequence, which is only found in NAD(P)H:quinone oxidoreductases and certain membrane-bound [NiFe]-hydrogenases expected to be involved in redox-linked proton translocation [FEBS Lett. 485 (2000) 1] [2].


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