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Gene Review:

YALI0E06831g - YALI0E06831p

Yarrowia lipolytica CLIB122

Titorenko, V.I. et al., Titorenko, V.I. et al.

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High impact information on PEX20

Import of the Aox complex into peroxisomes does not involve the cytosolic chaperone Pex20p, which mediates the oligomerization and import of peroxisomal thiolase [1].
Translocation of the thiolase homodimer into the peroxisomal matrix would release Pex20p monomers back to the cytosol, thereby permitting a new cycle of binding-oligomerization-targeting-release for Pex20p and thiolase [2].

Anatomical context of PEX20

Pex20p is mostly cytosolic, whereas 4-8% is associated with high-speed (200,000 g) pelletable peroxisomes [2].
Our data suggest that monomeric Pex20p binds newly synthesized monomeric thiolase in the cytosol and promotes the formation of a heterotetrameric complex of these two proteins, which could further bind to the peroxisomal membrane [2].

References

Acyl-CoA oxidase is imported as a heteropentameric, cofactor-containing complex into peroxisomes of Yarrowia lipolytica. Titorenko, V.I., Nicaud, J.M., Wang, H., Chan, H., Rachubinski, R.A. J. Cell Biol. (2002) [Pubmed]
Pex20p of the yeast Yarrowia lipolytica is required for the oligomerization of thiolase in the cytosol and for its targeting to the peroxisome. Titorenko, V.I., Smith, J.J., Szilard, R.K., Rachubinski, R.A. J. Cell Biol. (1998) [Pubmed]

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