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Gene Review:

TMOD4 - tropomodulin 4 (muscle)

Homo sapiens

Synonyms: Sk-Tmod, Skeletal muscle tropomodulin, Tropomodulin-4

Almenar-Queralt, A. et al., Cox, P.R. et al.

Cox, Siddique, Zoghbi,

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High impact information on TMOD4

Sk-Tmod is 62% identical in amino acid sequence to the previously described chicken E-Tmod and is the product of a different gene [1].
However, E- and Sk-Tmods differ in their tissue distribution; Sk-Tmod predominates in fast skeletal muscle fibers, lens, and erythrocytes, while E-Tmod is found in heart and slow skeletal muscle fibers [1].
CONCLUSIONS: The genomic structure of TMOD2 and TMOD4 have been delineated [2].
YL-1 encodes six exons, the last of which is 291 bp from a 5' untranslated exon of TMOD4 [2].

Analytical, diagnostic and therapeutic context of TMOD4

We used 5' RACE and RT-PCR from TMOD4 to identify several intergenic RACE products [2].

References

Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle. Almenar-Queralt, A., Lee, A., Conley, C.A., Ribas de Pouplana, L., Fowler, V.M. J. Biol. Chem. (1999) [Pubmed]
Genomic organization of Tropomodulins 2 and 4 and unusual intergenic and intraexonic splicing of YL-1 and Tropomodulin 4. Cox, P.R., Siddique, T., Zoghbi, H.Y. BMC Genomics (2001) [Pubmed]

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