High impact information on Mnt

• This approach also reveals dynamic interactions among network members as we find that increased levels of dMax influence the extent of dMyc, but not dMnt, binding [2].
• In support of this, dMyc, as well as its antagonist dMnt, are expressed in larval tissues in a pattern consistent with their involvement in regulating endoreplication [3].

Biological context of Mnt

• Our results indicate that larval growth and endoreplication are coupled processes that, although linked to cell cycle control mechanisms, are regulated by dMyc and dMnt [3].

Other interactions of Mnt

• We further show that the dMyc antagonist dMnt inhibits rRNA transcription in the wing disc [4].
• Myc, Mxd/Max, and Mnt proteins have been thought to act on a specific subset of genes [4].

Analytical, diagnostic and therapeutic context of Mnt

• Our results demonstrate that dMnt is a transcriptional repressor that regulates D. melanogaster body size [5].

References