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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Body Size

 
 
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Disease relevance of Body Size

 

Psychiatry related information on Body Size

 

High impact information on Body Size

  • The infants were examined systematically for the presence of major malformations, signs of hypoplasia of the midface and fingers, microcephaly, and small body size [11].
  • Cyclin D1-deficient animals develop to term but show reduced body size, reduced viability, and symptoms of neurological impairment [12].
  • The required intravenous dose of cyclosporine (expressed as milligrams per day) increased steeply as body size and bowel length increased, whereas the required oral dose declined with increasing bowel length [13].
  • We propose that in mammals c-Myc controls the decision to divide or not to divide and thereby functions as a crucial mediator of signals that determine organ and body size [14].
  • Drosophila deficient in the S6 kinase gene (dS6K) exhibited an extreme delay in development and a severe reduction in body size [15].
 

Chemical compound and disease context of Body Size

 

Biological context of Body Size

 

Anatomical context of Body Size

 

Associations of Body Size with chemical compounds

  • Here we present a new model of home range-body size scaling based on fractal resource distributions, in which resource encounter rates are a function of body size [6].
  • We conclude that body size and the deformity were the determinants of the lung volumes and the mechanical properties of the respiratory system, and that these variables were the major factors in both the magnitude and pattern of the ventilatory response to CO2 [31].
  • After adjusting for the effects of body size, M1 was also correlated and triglyceride [24].
  • Analyses of aba2/gin1 null mutants define dual functions of endogenous ABA in inhibiting the postgermination developmental switch modulated by distinct Glc and osmotic signals and in promoting organ and body size and fertility in the absence of severe stress [32].
  • Age, height, and CYP2C9 genotype significantly contributed to S-warfarin and total warfarin clearance, whereas only age and body size significantly contributed to R-warfarin clearance [33].
 

Gene context of Body Size

  • Interestingly, mice with a DNA-binding-deficient GR but an unaltered ability to interact with STAT5 (GR(dim/dim)) have a normal body size and normal levels of Stat5-dependent mRNAs [34].
  • The insulin-like growth factor I/insulin receptor substrate 1 axis controls, in a nonredundant way, approximately 50% of cell and body size in animals from Drosophila to mice and in cells in culture [35].
  • Our results demonstrate that dMnt is a transcriptional repressor that regulates D. melanogaster body size [36].
  • In addition, it is also required for body size determination and male tail patterning, roles which do not require daf-1 [37].
  • We propose that the sma-5 gene functions in a MAP kinase pathway to regulate body size mainly through control of cell growth [38].
 

Analytical, diagnostic and therapeutic context of Body Size

  • Carboplatin clearance (CL) values and volume of distribution (VC) were highly correlated to body size (CL = 55 x Body surface area in [BSA, in square meters] - 6.7, r2 = 0.73; VC = 5 x BSA [in square meters] + 0.26, r2 = 0.69) [39].
  • Size adjustment determined by using predefined indexes, such as BMD and body mass index (BMI, wt/ht2), may fail to correct BMC fully for bone and body size, and may lead to spurious associations with other size-related variables such as calcium intake, energy expenditure, and grip strength [40].
  • Fat free mass and height were found to be the best predictors of REE, and after accounting for these important body size and composition variables, differences in REE between boys and girls and CF and control groups increased over time [41].
  • Ghrelin, leptin, and adiponectin are associated with body size in cross-sectional studies; it is unknown whether these hormones predict long-term changes in body size [42].
  • Real-time PCR analysis showed an age/body size dependent increase in gastric ghrelin, which stagnated at 7 cm body size (onset of maturation) [43].

References

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  20. Graft-rejection and toxicity following bone marrow transplantation in relation to busulfan pharmacokinetics. Slattery, J.T., Sanders, J.E., Buckner, C.D., Schaffer, R.L., Lambert, K.W., Langer, F.P., Anasetti, C., Bensinger, W.I., Fisher, L.D., Appelbaum, F.R. Bone Marrow Transplant. (1995) [Pubmed]
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  23. SOCS2 negatively regulates growth hormone action in vitro and in vivo. Greenhalgh, C.J., Rico-Bautista, E., Lorentzon, M., Thaus, A.L., Morgan, P.O., Willson, T.A., Zervoudakis, P., Metcalf, D., Street, I., Nicola, N.A., Nash, A.D., Fabri, L.J., Norstedt, G., Ohlsson, C., Flores-Morales, A., Alexander, W.S., Hilton, D.J. J. Clin. Invest. (2005) [Pubmed]
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  29. Males have larger skeletal size and bone mass than females, despite comparable body size. Nieves, J.W., Formica, C., Ruffing, J., Zion, M., Garrett, P., Lindsay, R., Cosman, F. J. Bone Miner. Res. (2005) [Pubmed]
  30. Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland. Lee, A.V., Zhang, P., Ivanova, M., Bonnette, S., Oesterreich, S., Rosen, J.M., Grimm, S., Hovey, R.C., Vonderhaar, B.K., Kahn, C.R., Torres, D., George, J., Mohsin, S., Allred, D.C., Hadsell, D.L. Endocrinology (2003) [Pubmed]
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