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Gene Review:

HLA-J - major histocompatibility complex, class I,...

Homo sapiens

Synonyms: CDA12, D6S203, HLA-59, HLA-CDA12

Dunn, D.S. et al., Messer, G. et al., Ando, A. et al., Elsner, H.A. et al.

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High impact information on HLA-J

Ragoussis and co-workers (Genomics 4:301) previously described a class I HLA gene (now designated HLA-J) that maps to within 50 kb of HLA-A [1].
The nucleotide sequences of three HLA-J alleles are reported here [1].
We have identified another two new polymorphic Alu insertions, AluyHJ and AluyHF, located near HLA-J and HLA-F, respectively, within the a block of the MHC [2].
The association between HLA-A alleles and young Alu dimorphisms near the HLA-J, -H, and -F genes in workshop cell lines and Japanese and Australian populations [2].
In contrast, a human segment (alpha block) spanning about 375 kb from the gene ETF1P1 and from the HLA-J to HLA-F genes was absent from the 238-kb swine segment [3].

Biological context of HLA-J

This insertion may be explained either by conversion with the pseudogene HLA-J or by slipped-strand mispairing [4].

References

HLA-J, a second inactivated class I HLA gene related to HLA-G and HLA-A. Implications for the evolution of the HLA-A-related genes. Messer, G., Zemmour, J., Orr, H.T., Parham, P., Weiss, E.H., Girdlestone, J. J. Immunol. (1992) [Pubmed]
The association between HLA-A alleles and young Alu dimorphisms near the HLA-J, -H, and -F genes in workshop cell lines and Japanese and Australian populations. Dunn, D.S., Naruse, T., Inoko, H., Kulski, J.K. J. Mol. Evol. (2002) [Pubmed]
Genomic sequence analysis of the 238-kb swine segment with a cluster of TRIM and olfactory receptor genes located, but with no class I genes, at the distal end of the SLA class I region. Ando, A., Shigenari, A., Kulski, J.K., Renard, C., Chardon, P., Shiina, T., Inoko, H. Immunogenetics (2005) [Pubmed]
Non-expression of HLA-B*5111N is caused by an insertion into the cytosine island at exon 4 creating a frameshift stop codon. Elsner, H.A., Drábek, J., Rebmann, V., Ambruzova, Z., Grosse-Wilde, H., Blasczyk, R. Tissue Antigens (2001) [Pubmed]

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