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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

pon  -  partner of numb

Drosophila melanogaster

Synonyms: CG3346, Dmel\CG3346, PON, Pon
 
 
 
 
 
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High impact information on pon

  • Loss of pon function disrupts Numb localization in muscle progenitors and delays Numb crescent formation in neural precursors [1].
  • We propose that PON is one component of a multimolecular machinery that localizes Numb by responding to polarity cues conserved in neural precursors and epithelial cells [1].
  • PON is asymmetrically localized during mitosis and colocalizes with Numb [1].
 

Anatomical context of pon

  • Moreover, ectopically expressed PON responds to the apical-basal polarity of epithelial cells and is sufficient to localize Numb basally [1].
 

Other interactions of pon

  • Here we report the identification of a novel gene product, Partner of Numb (PON), based on its physical interaction with Numb [1].

References

  1. Partner of Numb colocalizes with Numb during mitosis and directs Numb asymmetric localization in Drosophila neural and muscle progenitors. Lu, B., Rothenberg, M., Jan, L.Y., Jan, Y.N. Cell (1998) [Pubmed]
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