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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Epithelial Cells

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Disease relevance of Epithelial Cells


Psychiatry related information on Epithelial Cells


High impact information on Epithelial Cells

  • Later, at the CD4+8+ stage, as well as providing low avidity TCR/MHC-peptide interactions, thymic epithelial cells have been shown to possess unique properties essential for positive selection [11].
  • Finally, as other members of the tumor necrosis factor receptor family have been shown to bind several ligands, it is possible that CD40 may bind other ligands that may trigger CD40 on different cell types such as hematopoietic cells or epithelial cells [12].
  • The best studied example of this is the transport of polymeric IgA and IgM by the polymeric immunoglobulin receptor (pIgR) across many types of epithelial cells [13].
  • Although multiple integrins on airway epithelial cells may support adhesion to the same ligands, the functional roles of each integrin that has been examined in detail are quite distinct [14].
  • Moreover, this function has been localized to the apical membrane of chloride secretory epithelial cells [15].

Chemical compound and disease context of Epithelial Cells


Biological context of Epithelial Cells


Anatomical context of Epithelial Cells


Associations of Epithelial Cells with chemical compounds

  • These go through the intricate process of mesenchyme-to-epithelium transition by which epithelial cell polarization is initiated, and they continue to differentiate into the highly specialized epithelial cell populations of the nephron [31].
  • Binding studies with tritiated oxytocin and vasopressin have permitted determination of the kinetic parameters of hormone-receptor interaction in amphibian epithelial cells and mammalian kidney [32].
  • Most of the butyrate is converted to ketone bodies or CO2 by the epithelial cells, and nearly all of the remainder is removed by the liver [26].
  • Here, we identify the product of human MTA3 as an estrogen-dependent component of the Mi-2/NuRD transcriptional corepressor in breast epithelial cells and demonstrate that MTA3 constitutes a key component of an estrogen-dependent pathway regulating growth and differentiation [33].
  • Moreover, the wild-type allele of TLR4 rescues the LPS hyporesponsive phenotype in either primary airway epithelial cells or alveolar macrophages obtained from individuals with the TLR4 mutations [34].

Gene context of Epithelial Cells

  • We present results from whole-cell and single-channel patch-clamp recordings, short-circuit current recordings, and [gamma-32P]ATP release assays of normal, CF, and wild-type or mutant CFTR-transfected CF airway cultured epithelial cells wherein CFTR regulates ORCCs by triggering the transport of the potent agonist, ATP, out of the cell [35].
  • The response of human epithelial cells to TNF involves an inducible autocrine cascade [36].
  • Both cyclin D1 and estrogens have an essential role in regulating proliferation of breast epithelial cells [37].
  • The physiological expression of TERT within normal epithelial cells that retain proliferative potential and its presence at the earliest stages of tumorigenesis have implications for the regulation of telomerase expression and for the identification of cells that may be targets for malignant transformation [38].
  • Syndecan-1 is a cell-surface, heparan-sulphate proteoglycan (HSPG) predominantly expressed by epithelial cells [39].

Analytical, diagnostic and therapeutic context of Epithelial Cells


  1. Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. Thompson, M.E., Jensen, R.A., Obermiller, P.S., Page, D.L., Holt, J.T. Nat. Genet. (1995) [Pubmed]
  2. Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis. Hill, R., Song, Y., Cardiff, R.D., Van Dyke, T. Cell (2005) [Pubmed]
  3. Causal relationship between the loss of RUNX3 expression and gastric cancer. Li, Q.L., Ito, K., Sakakura, C., Fukamachi, H., Inoue, K., Chi, X.Z., Lee, K.Y., Nomura, S., Lee, C.W., Han, S.B., Kim, H.M., Kim, W.J., Yamamoto, H., Yamashita, N., Yano, T., Ikeda, T., Itohara, S., Inazawa, J., Abe, T., Hagiwara, A., Yamagishi, H., Ooe, A., Kaneda, A., Sugimura, T., Ushijima, T., Bae, S.C., Ito, Y. Cell (2002) [Pubmed]
  4. Activation of chloride channels in normal and cystic fibrosis airway epithelial cells by multifunctional calcium/calmodulin-dependent protein kinase. Wagner, J.A., Cozens, A.L., Schulman, H., Gruenert, D.C., Stryer, L., Gardner, P. Nature (1991) [Pubmed]
  5. The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells. Coopman, P.J., Do, M.T., Barth, M., Bowden, E.T., Hayes, A.J., Basyuk, E., Blancato, J.K., Vezza, P.R., McLeskey, S.W., Mangeat, P.H., Mueller, S.C. Nature (2000) [Pubmed]
  6. Fractalkine-mediated signals regulate cell-survival and immune-modulatory responses in intestinal epithelial cells. Brand, S., Sakaguchi, T., Gu, X., Colgan, S.P., Reinecker, H.C. Gastroenterology (2002) [Pubmed]
  7. Leptin is a growth factor for colonic epithelial cells. Hardwick, J.C., Van Den Brink, G.R., Offerhaus, G.J., Van Deventer, S.J., Peppelenbosch, M.P. Gastroenterology (2001) [Pubmed]
  8. Nephrogenic diabetes insipidus in sibling colts. Schott, H.C., Bayly, W.M., Reed, S.M., Brobst, D.F. J. Vet. Intern. Med. (1993) [Pubmed]
  9. Influence of luminal pH on rat large bowel epithelial cell cycle. Lupton, J.R., Coder, D.M., Jacobs, L.R. Am. J. Physiol. (1985) [Pubmed]
  10. Carbonic anhydrase activity during development of the choroid plexus in the human fetus. Catala, M. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. (1997) [Pubmed]
  11. Cellular interactions in thymocyte development. Anderson, G., Moore, N.C., Owen, J.J., Jenkinson, E.J. Annu. Rev. Immunol. (1996) [Pubmed]
  12. The CD40 antigen and its ligand. Banchereau, J., Bazan, F., Blanchard, D., Brière, F., Galizzi, J.P., van Kooten, C., Liu, Y.J., Rousset, F., Saeland, S. Annu. Rev. Immunol. (1994) [Pubmed]
  13. Transepithelial transport of immunoglobulins. Mostov, K.E. Annu. Rev. Immunol. (1994) [Pubmed]
  14. Functions of pulmonary epithelial integrins: from development to disease. Sheppard, D. Physiol. Rev. (2003) [Pubmed]
  15. Intracellular CFTR: localization and function. Bradbury, N.A. Physiol. Rev. (1999) [Pubmed]
  16. Neutral endopeptidase 24.11 loss in metastatic human prostate cancer contributes to androgen-independent progression. Papandreou, C.N., Usmani, B., Geng, Y., Bogenrieder, T., Freeman, R., Wilk, S., Finstad, C.L., Reuter, V.E., Powell, C.T., Scheinberg, D., Magill, C., Scher, H.I., Albino, A.P., Nanus, D.M. Nat. Med. (1998) [Pubmed]
  17. Group A Streptococcus tissue invasion by CD44-mediated cell signalling. Cywes, C., Wessels, M.R. Nature (2001) [Pubmed]
  18. Primary intestinal epithelial cells selectively transfer R5 HIV-1 to CCR5+ cells. Meng, G., Wei, X., Wu, X., Sellers, M.T., Decker, J.M., Moldoveanu, Z., Orenstein, J.M., Graham, M.F., Kappes, J.C., Mestecky, J., Shaw, G.M., Smith, P.D. Nat. Med. (2002) [Pubmed]
  19. Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections. Pier, G.B., Grout, M., Zaidi, T.S., Olsen, J.C., Johnson, L.G., Yankaskas, J.R., Goldberg, J.B. Science (1996) [Pubmed]
  20. Grb2 is a key mediator of helicobacter pylori CagA protein activities. Mimuro, H., Suzuki, T., Tanaka, J., Asahi, M., Haas, R., Sasakawa, C. Mol. Cell (2002) [Pubmed]
  21. Human surfactant protein B: structure, function, regulation, and genetic disease. Whitsett, J.A., Nogee, L.M., Weaver, T.E., Horowitz, A.D. Physiol. Rev. (1995) [Pubmed]
  22. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Tsujii, M., DuBois, R.N. Cell (1995) [Pubmed]
  23. BAC-mediated gene-dosage analysis reveals a role for Zipro1 (Ru49/Zfp38) in progenitor cell proliferation in cerebellum and skin. Yang, X.W., Wynder, C., Doughty, M.L., Heintz, N. Nat. Genet. (1999) [Pubmed]
  24. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Xu, X., Wagner, K.U., Larson, D., Weaver, Z., Li, C., Ried, T., Hennighausen, L., Wynshaw-Boris, A., Deng, C.X. Nat. Genet. (1999) [Pubmed]
  25. Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene. Bouchard, L., Lamarre, L., Tremblay, P.J., Jolicoeur, P. Cell (1989) [Pubmed]
  26. Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Bergman, E.N. Physiol. Rev. (1990) [Pubmed]
  27. Multiple sites for the initiation of microtubule assembly in mammalian cells. Spiegelman, B.M., Lopata, M.A., Kirschner, M.W. Cell (1979) [Pubmed]
  28. Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila. Wodarz, A., Hinz, U., Engelbert, M., Knust, E. Cell (1995) [Pubmed]
  29. c-fos expression interferes with thymus development in transgenic mice. Rüther, U., Müller, W., Sumida, T., Tokuhisa, T., Rajewsky, K., Wagner, E.F. Cell (1988) [Pubmed]
  30. LIN-10 is a shared component of the polarized protein localization pathways in neurons and epithelia. Rongo, C., Whitfield, C.W., Rodal, A., Kim, S.K., Kaplan, J.M. Cell (1998) [Pubmed]
  31. Embryonic renal epithelia: induction, nephrogenesis, and cell differentiation. Horster, M.F., Braun, G.S., Huber, S.M. Physiol. Rev. (1999) [Pubmed]
  32. Stimulus-response coupling in neurohypophysial peptide target cells. Jard, S., Bockaert, J. Physiol. Rev. (1975) [Pubmed]
  33. MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. Fujita, N., Jaye, D.L., Kajita, M., Geigerman, C., Moreno, C.S., Wade, P.A. Cell (2003) [Pubmed]
  34. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Arbour, N.C., Lorenz, E., Schutte, B.C., Zabner, J., Kline, J.N., Jones, M., Frees, K., Watt, J.L., Schwartz, D.A. Nat. Genet. (2000) [Pubmed]
  35. CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP. Schwiebert, E.M., Egan, M.E., Hwang, T.H., Fulmer, S.B., Allen, S.S., Cutting, G.R., Guggino, W.B. Cell (1995) [Pubmed]
  36. The response of human epithelial cells to TNF involves an inducible autocrine cascade. Janes, K.A., Gaudet, S., Albeck, J.G., Nielsen, U.B., Lauffenburger, D.A., Sorger, P.K. Cell (2006) [Pubmed]
  37. CDK-independent activation of estrogen receptor by cyclin D1. Zwijsen, R.M., Wientjens, E., Klompmaker, R., van der Sman, J., Bernards, R., Michalides, R.J. Cell (1997) [Pubmed]
  38. Expression of TERT in early premalignant lesions and a subset of cells in normal tissues. Kolquist, K.A., Ellisen, L.W., Counter, C.M., Meyerson, M., Tan, L.K., Weinberg, R.A., Haber, D.A., Gerald, W.L. Nat. Genet. (1998) [Pubmed]
  39. Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice. Alexander, C.M., Reichsman, F., Hinkes, M.T., Lincecum, J., Becker, K.A., Cumberledge, S., Bernfield, M. Nat. Genet. (2000) [Pubmed]
  40. De novo synthesis and specific assembly of keratin filaments in nonepithelial cells after microinjection of mRNA for epidermal keratin. Kreis, T.E., Geiger, B., Schmid, E., Jorcano, J.L., Franke, W.W. Cell (1983) [Pubmed]
  41. The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Fata, J.E., Kong, Y.Y., Li, J., Sasaki, T., Irie-Sasaki, J., Moorehead, R.A., Elliott, R., Scully, S., Voura, E.B., Lacey, D.L., Boyle, W.J., Khokha, R., Penninger, J.M. Cell (2000) [Pubmed]
  42. E-cadherin is the receptor for internalin, a surface protein required for entry of L. monocytogenes into epithelial cells. Mengaud, J., Ohayon, H., Gounon, P., Mege R-M, n.u.l.l., Cossart, P. Cell (1996) [Pubmed]
  43. Transforming growth factor beta as a predictor of liver and lung fibrosis after autologous bone marrow transplantation for advanced breast cancer. Anscher, M.S., Peters, W.P., Reisenbichler, H., Petros, W.P., Jirtle, R.L. N. Engl. J. Med. (1993) [Pubmed]
  44. Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans. Grubb, B.R., Pickles, R.J., Ye, H., Yankaskas, J.R., Vick, R.N., Engelhardt, J.F., Wilson, J.M., Johnson, L.G., Boucher, R.C. Nature (1994) [Pubmed]
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