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Gene Review:

bclA - benzoate-CoA ligase

Aromatoleum aromaticum EbN1

López Barragán, M.J. et al., Mohamed, M.E. et al.

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Disease relevance of bclA

Benzoate-CoA ligase assays and transcriptional analyses based on lacZ-reporter fusions revealed that benzoate degradation in Azoarcus sp. strain CIB is subject to carbon catabolite repression by some organic acids, indicating the existence of a physiological control that connects the expression of the bzd genes to the metabolic status of the cell [1].

Associations of bclA with chemical compounds

The first committed step is the activation of benzoate to benzoyl-CoA by a specifically induced benzoate-CoA ligase (AMP forming) [2].

References

The bzd gene cluster, coding for anaerobic benzoate catabolism, in Azoarcus sp. strain CIB. López Barragán, M.J., Carmona, M., Zamarro, M.T., Thiele, B., Boll, M., Fuchs, G., García, J.L., Díaz, E. J. Bacteriol. (2004) [Pubmed]
Reinvestigation of a new type of aerobic benzoate metabolism in the proteobacterium Azoarcus evansii. Mohamed, M.E., Zaar, A., Ebenau-Jehle, C., Fuchs, G. J. Bacteriol. (2001) [Pubmed]

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