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Gene Review

Sk1  -  Sphingosine kinase 1

Drosophila melanogaster

Synonyms: CG1747, Dmel\CG1747, SK1, Sphk1
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High impact information on Sk1

  • Both genes functionally and biochemically complement a yeast sphingosine kinase mutant, express predominantly cytosolic activities, and are capable of phosphorylating a range of endogenous and non-endogenous sphingoid base substrates [1].
  • Sphingosine kinase is a highly conserved enzyme that catalyzes the synthesis of sphingosine 1-phosphate and reduces cellular levels of sphingosine and ceramide [1].


  1. Characterization of the Drosophila sphingosine kinases and requirement for Sk2 in normal reproductive function. Herr, D.R., Fyrst, H., Creason, M.B., Phan, V.H., Saba, J.D., Harris, G.L. J. Biol. Chem. (2004) [Pubmed]
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