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Gene Review

Sk1  -  Sphingosine kinase 1

Drosophila melanogaster

Synonyms: CG1747, Dmel\CG1747, SK1, Sphk1
 
 
 
 
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High impact information on Sk1

  • Both genes functionally and biochemically complement a yeast sphingosine kinase mutant, express predominantly cytosolic activities, and are capable of phosphorylating a range of endogenous and non-endogenous sphingoid base substrates [1].
  • Sphingosine kinase is a highly conserved enzyme that catalyzes the synthesis of sphingosine 1-phosphate and reduces cellular levels of sphingosine and ceramide [1].

References

  1. Characterization of the Drosophila sphingosine kinases and requirement for Sk2 in normal reproductive function. Herr, D.R., Fyrst, H., Creason, M.B., Phan, V.H., Saba, J.D., Harris, G.L. J. Biol. Chem. (2004) [Pubmed]
 
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