The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Sphk2  -  sphingosine kinase 2

Mus musculus

Synonyms: C76851, SK 2, SPK 2, Sphingosine kinase 2
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Sphk2


Anatomical context of Sphk2

  • Expression of SK1 and SK2 proteins revealed a partly overlapping distribution pattern restricted to a limited number of brain areas (e.g., neocortex, hippocampal formation) [4].

Associations of Sphk2 with chemical compounds

  • SK activity was measured by an in vitro kinase assay using sphingosine as substrate.Key results:Nucleotide stimulation caused biphasic activation of SK-1, but not SK-2 [5].

Regulatory relationships of Sphk2

  • Such findings appear to reflect a requirement for Sphk2 to suppress IL-2 signaling because, in Sphk2(-/-) CD4(+) T cells, IL-2 induced abnormally accentuated STAT5 phosphorylation and small interfering RNA knockdown of STAT5 abrogated their hyperactive phenotype [6].


  1. Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720. Zemann, B., Kinzel, B., Müller, M., Reuschel, R., Mechtcheriakova, D., Urtz, N., Bornancin, F., Baumruker, T., Billich, A. Blood (2006) [Pubmed]
  2. Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. Kharel, Y., Lee, S., Snyder, A.H., Sheasley-O'neill, S.L., Morris, M.A., Setiady, Y., Zhu, R., Zigler, M.A., Burcin, T.L., Ley, K., Tung, K.S., Engelhard, V.H., Macdonald, T.L., Pearson-White, S., Lynch, K.R. J. Biol. Chem. (2005) [Pubmed]
  3. Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. Sanchez, T., Estrada-Hernandez, T., Paik, J.H., Wu, M.T., Venkataraman, K., Brinkmann, V., Claffey, K., Hla, T. J. Biol. Chem. (2003) [Pubmed]
  4. Comparative immunohistochemical distribution of three small-conductance Ca2+-activated potassium channel subunits, SK1, SK2, and SK3 in mouse brain. Sailer, C.A., Kaufmann, W.A., Marksteiner, J., Knaus, H.G. Mol. Cell. Neurosci. (2004) [Pubmed]
  5. Extracellular nucleotides induce migration of renal mesangial cells by upregulating sphingosine kinase-1 expression and activity. Klawitter, S., Hofmann, L.P., Pfeilschifter, J., Huwiler, A. Br. J. Pharmacol. (2007) [Pubmed]
  6. Cutting edge: Modulation of intestinal autoimmunity and IL-2 signaling by sphingosine kinase 2 independent of sphingosine 1-phosphate. Samy, E.T., Meyer, C.A., Caplazi, P., Langrish, C.L., Lora, J.M., Bluethmann, H., Peng, S.L. J. Immunol. (2007) [Pubmed]
WikiGenes - Universities